Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 201 to 225 of 1145 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
945 occurrence vesicle targeting, plasma membrane to endosome (GO:0048201) None
944 occurrence clathrin-dependent endocytosis (GO:0072583) None
943 increased acute-phase response (GO:0006953) Acute phase proteins (N/A)
942 increased Atherosclerosis (HP:0002621) 1443: Atherosclerosis
941 increased acute-phase response (GO:0006953) None
940 decreased decreased body weight (MP:0001262) 864: Decreased, Body Weight
939 decreased sexual reproduction (GO:0019953) 2147: Decreased, Viable Offspring
938 decreased toll-like receptor 3 signaling pathway (GO:0034138) influenzavirus NS gene translation product (PR:000044794) 2180: Immune mechanisms antagonized by viral proteins
937 decreased toll-like receptor 7 signaling pathway (GO:0034154) influenzavirus NS gene translation product (PR:000044794) 2180: Immune mechanisms antagonized by viral proteins
936 decreased toll-like receptor 3 signaling pathway (GO:0034138) viral genome (GO:0019015) None
935 occurrence toll-like receptor 7 signaling pathway (GO:0034154) viral genome (GO:0019015) None
934 occurrence toll-like receptor 3 signaling pathway (GO:0034138) viral genome (GO:0019015) None
933 occurrence inhibition of host DNA replication by virus (GO:0098673) interferon regulatory factor 3 complex (GO:0097072) None
932 occurrence membrane fusion (GO:0061025) vesicle membrane (GO:0012506) 2159: Influenza A virus (IAV) cell entry
931 occurrence receptor-mediated endocytosis (GO:0006898) influenzavirus hemagglutinin (PR:000049750) 2159: Influenza A virus (IAV) cell entry
930 occurrence protein localization to endosome (GO:0036010) clathrin-coated vesicle membrane (GO:0030665) 2159: Influenza A virus (IAV) cell entry
929 occurrence receptor-mediated endocytosis (GO:0006898) clathrin-coated vesicle membrane (GO:0030665) None
928 occurrence receptor binding (GO:0005102)
927 disrupted intercellular transport (GO:0010496) 2096: Occurrence, (Micro)vascular dysfunction
926 functional change smooth muscle cell (CL:0000192) 2096: Occurrence, (Micro)vascular dysfunction
925 functional change pericyte cell (CL:0000669) 2096: Occurrence, (Micro)vascular dysfunction
924 functional change blood vessel endothelial cell (CL:0000071) 2096: Occurrence, (Micro)vascular dysfunction
923 decreased signaling (GO:0023052) neurotransmitter (CHEBI:25512) 2151: Disruption, neurotransmitter release
922 increased calcium amount (VT:0010499) calcium(2+) (CHEBI:29108) 1339: Increase, intracellular calcium
921 increased kinase activity (GO:0016301) astrocyte (CL:0000127) 2146: Activation of mitogen-activated protein kinase kinase, extracellular signal-regulated kinase 1/2