Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 501 to 525 of 1159 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
659 increased male reproductive organ (UBERON:0003135) 1209: Induction, Male reproductive tract
658 increased male organism (UBERON:0003101) 1208: Increased, Male offspring
657 increased offspring quantity (VT:1000189) 1208: Increased, Male offspring
656 increased gene expression (GO:0010467) protein doublesex (fruit fly) (PR:P23023) 1206: Induction, Doublesex1 gene
655 increased signaling (GO:0023052) juvenile hormone (CHEBI:24943) 1205: Activation, Juvenile hormone receptor
654 increased second-messenger-mediated signaling (GO:0019932) 1242: Increased, Second Messenger Production
653 increased cell motility (GO:0048870) 1241: Increased, Motility
652 abnormal translation (GO:0006412) protein (PR:000000001) 1240: Altered, Protein Production
651 abnormal gene expression (GO:0010467) 1239: Altered, Gene Expression
650 increased angiogenesis (GO:0001525) 1213: Increased, Angiogenesis
649 decreased macrophage activation (GO:0042116) 1198: Activation, Macrophages
648 decreased cell activation (GO:0001775) 1197: Activation, Fibroblasts
647 increased epithelial cell (CL:0000066) 1196: Increased, Invasion
646 morphological change extracellular matrix (GO:0031012) 1195: modulation, Extracellular Matrix Composition
645 functional change deoxyribonucleic acid (CHEBI:16991) 1194: Increase, DNA damage
644 pathological Breast Neoplasms (MESH:D001943) 1193: N/A, Breast Cancer
643 increased signaling (GO:0023052) 1191: Increased, Non-genomic signaling
642 increased endothelial cell migration (GO:0043542) 1190: Increased, Migration (Endothelial Cells)
641 increased endothelial cell proliferation (GO:0001935) 1189: Increased, Proliferation (Endothelial cells)
640 increased estrogen receptor binding (GO:0030331) serotransferrin (PR:000016261) 1188: Increased, ER binding to T.F. to DNA (non-classical pathway)
639 increased estrogen receptor binding (GO:0030331) deoxyribonucleic acid (CHEBI:16991) 1187: Increased, ER binding to DNA (classical pathway)
638 increased signaling (GO:0023052) estrogen receptor (PR:000007204) None
637 decreased transport (GO:0006810) gamma-aminobutyric acid (CHEBI:16865) 1179: Decreased, GABA release
636 decreased transport (GO:0006810) sodium(1+) (CHEBI:29101) 1176: Decreased, sodium conductance 2
635 decreased signaling (GO:0023052) sodium channel protein type 1 subunit alpha (PR:000002095) 584: Inhibition, sodium channel