Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 901 to 925 of 1159 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
259 increased gene expression (GO:0010467) apolipoprotein B-100 (PR:000004145) 880: Increased, ApoB100
258 increased signaling (GO:0023052) microsomal triglyceride transfer protein large subunit MTTP (PR:000003392) 879: Activation, MTTP
257 decreased catalytic activity (GO:0003824) 17-beta-hydroxysteroid dehydrogenase 14 (PR:000008778) 482: Decreased, DHB4/HSD17B4
256 increased signaling (GO:0023052) nuclear receptor subfamily 0 group B member 2 (PR:000011391) 480: Activation, SHP
255 increased signaling (GO:0023052) bile acid receptor (PR:000011396) 479: Activation, NR1H4
254 increased signaling (GO:0023052) nuclear factor erythroid 2-related factor 2 (PR:000011170) 478: Activation, NRF2
253 increased biosynthetic process (GO:0009058) triglyceride (CHEBI:17855)
252 decreased gene expression (GO:0010467) hydroxymethylglutaryl-CoA synthase, mitochondrial (PR:000008638) 474: Down Regulation, HMGCS2
251 decreased gene expression (GO:0010467) carnitine O-palmitoyltransferase 1, liver isoform (PR:000005835) 472: Down Regulation, CPT1A
250 decreased signaling (GO:0023052) hepatocyte nuclear factor 3-beta (PR:000007603) 471: Inhibition, FoxA2
249 decreased signaling (GO:0023052) hepatocyte nuclear factor 4-alpha (PR:000008654) 461: Suppression, HNF4alpha
248 increased acetyl-CoA carboxylase activity (GO:0003989) acetyl-CoA carboxylase 1 (PR:000003596) 470: Up Regulation, Acetyl-CoA carboxylase-1 (ACC-1)
247 increased gene expression (GO:0010467) fatty acid synthase (PR:000007348) 463: Up Regulation, FAS
246 increased triglyceride biosynthetic process (GO:0019432) triglyceride (CHEBI:17855) 454: Increased, Triglyceride formation
245 increased signaling (GO:0023052) sterol regulatory element-binding protein 1 (PR:000015611) 457: Activation, SREBF1
244 decreased signaling (GO:0023052) nuclear receptor subfamily 1 group I member 3 (PR:000011398) 456: Suppression, Constitutive androstane receptor, NR1I3
243 increased gene expression (GO:0010467) cytochrome P450 1A1 (PR:000006101) 80: Up Regulation, CYP1A1
242 increased receptor-mediated endocytosis (GO:0006898) low-density lipoprotein (CHEBI:39026) 467: Increased, LDL uptake
241 increased gene expression (GO:0010467) low-density lipoprotein receptor (PR:000009744) 466: Up Regulation, LDLR (low density lipoprotein receptor)
240 increased fatty acid transport (GO:0015908) fatty acid (CHEBI:35366) 465: Increased, Fatty acid influx
239 decreased gene expression (GO:0010467) phosphoenolpyruvate carboxykinase, cytosolic [GTP] (PR:000012416) 216: Decreased, PCK1 expression (control point for glycolysis/gluconeogenesis pathway)
238 decreased secretion (GO:0046903) very-low-density lipoprotein (CHEBI:39027) 450: Decrease, Very low-density lipoprotein export capacity
237 abnormal abnormal neuron morphology (MP:0002882) 851: Decrease of GABAergic interneurons
236 decreased iodide transport (GO:0015705) iodide (CHEBI:16382)
235 decreased sodium:iodide symporter activity (GO:0008507) sodium/iodide cotransporter (PR:000015171) 424: Inhibition, Na+/I- symporter (NIS)