This AOP is licensed under the BY-SA license. This license allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use. If you remix, adapt, or build upon the material, you must license the modified material under identical terms.
AOP: 110
Title
Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse)
Short name
Graphical Representation
Point of Contact
Contributors
- Charles Wood
Coaches
OECD Information Table
OECD Project # | OECD Status | Reviewer's Reports | Journal-format Article | OECD iLibrary Published Version |
---|---|---|---|---|
1.29 |
This AOP was last modified on April 29, 2023 16:02
Revision dates for related pages
Page | Revision Date/Time |
---|---|
Increase, Hypertrophy and proliferation (follicular cell) | September 16, 2017 10:16 |
Increase, Hyperplasia (follicular cells) | September 16, 2017 10:16 |
Increase, Adenomas/carcinomas (follicular cell) | September 16, 2017 10:16 |
Thyroid hormone synthesis, Decreased | November 04, 2022 09:25 |
Thyroxine (T4) in serum, Decreased | October 10, 2022 08:52 |
Increased, Thyroid-stimulating hormone (TSH) | September 16, 2017 10:17 |
Inhibition, Na+/I- symporter (NIS) | April 04, 2019 08:52 |
Inhibition, Na+/I- symporter (NIS) leads to TH synthesis, Decreased | December 03, 2016 16:37 |
TH synthesis, Decreased leads to T4 in serum, Decreased | October 10, 2022 08:56 |
T4 in serum, Decreased leads to Increased, Thyroid-stimulating hormone (TSH) | July 07, 2021 09:49 |
Increased, Thyroid-stimulating hormone (TSH) leads to Increase, Hypertrophy and proliferation (follicular cell) | July 07, 2021 10:17 |
Increase, Hypertrophy and proliferation (follicular cell) leads to Increase, Hyperplasia (follicular cells) | December 03, 2016 16:38 |
Increase, Hyperplasia (follicular cells) leads to Increase, Adenomas/carcinomas (follicular cell) | December 03, 2016 16:38 |
Abstract
This putative adverse outcome pathway (AOP) outlines potential key events leading to a tumor outcome in standard carcinogenicity models. This information is based largely on modes of action described previously in cited literature sources and is intended as a resource template for AOP development and data organization. Presentation in this Wiki does not indicate EPA acceptance of a particular pathway for a given reference agent, only that the information has been proposed in some manner. In addition, this putative AOP relates to the model species indicated and does not directly address issues of human relevance
AOP Development Strategy
Context
Strategy
Summary of the AOP
Events:
Molecular Initiating Events (MIE)
Key Events (KE)
Adverse Outcomes (AO)
Type | Event ID | Title | Short name |
---|
MIE | 424 | Inhibition, Na+/I- symporter (NIS) | Inhibition, Na+/I- symporter (NIS) |
KE | 277 | Thyroid hormone synthesis, Decreased | TH synthesis, Decreased |
KE | 281 | Thyroxine (T4) in serum, Decreased | T4 in serum, Decreased |
KE | 1023 | Increased, Thyroid-stimulating hormone (TSH) | Increased, Thyroid-stimulating hormone (TSH) |
KE | 739 | Increase, Hypertrophy and proliferation (follicular cell) | Increase, Hypertrophy and proliferation (follicular cell) |
KE | 740 | Increase, Hyperplasia (follicular cells) | Increase, Hyperplasia (follicular cells) |
AO | 741 | Increase, Adenomas/carcinomas (follicular cell) | Increase, Adenomas/carcinomas (follicular cell) |
Relationships Between Two Key Events (Including MIEs and AOs)
Title | Adjacency | Evidence | Quantitative Understanding |
---|
Network View
Prototypical Stressors
Life Stage Applicability
Taxonomic Applicability
Sex Applicability
Sex | Evidence |
---|---|
Male |
Overall Assessment of the AOP
Domain of Applicability
Essentiality of the Key Events
Evidence Assessment
Known Modulating Factors
Quantitative Understanding
Considerations for Potential Applications of the AOP (optional)
References
Dellarco, V. L., McGregor, D., Berry, S. C., Cohen, S. M., & Boobis, A. R. (2006). Thiazopyr and thyroid disruption: case study within the context of the 2006 IPCS Human Relevance Framework for analysis of a cancer mode of action. Crit Rev Toxicol, 36(10), 793-801. doi: 10.1080/10408440600975242
U.S. Environmental Protection Agency, R. A. F. (Mar. 1998). Assessment of Thyroid Follicular Cell Tumors. Washington, DC.
Hurley, P. M. (1998). Mode of carcinogenic action of pesticides inducing thyroid follicular cell tumors in rodents. Environ Health Perspect, 106(8), 437-445.
Wolff, J. (1998). Perchlorate and the thyroid gland. Pharmacol Rev, 50(1), 89-105.