API

Aop: 192

AOP Title

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Pendrin inhibition leading to altered amphibian metamorphosis

Short name:

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Pendrin inhib alters metamorphosis

Authors

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Jonathan T. Haselman, National Health and Environmental Effects Research Laboratory, US EPA, Duluth, MN, USA <haselman.jon@epa.gov>

Sigmund J. Degitz, National Health and Environmental Effects Research Laboratory, US EPA, Duluth, MN, USA <degitz.sigmund@epa.gov>

Michael W. Hornung, National Health and Environmental Effects Research Laboratory, US EPA, Duluth, MN, USA <hornung.michael@epa.gov>

Point of Contact

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Jonathan Haselman

Contributors

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  • Jonathan Haselman

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development 1.29 Included in OECD Work Plan


This AOP was last modified on December 03, 2016 16:37

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Revision dates for related pages

Page Revision Date/Time
Inhibition, Pendrin December 03, 2016 16:37
Thyroid hormone synthesis, Decreased September 17, 2017 18:27
Decreased, Thyroxine (T4) in serum September 16, 2017 10:16
Decreased, Thyroxine (T4) in tissues November 29, 2016 19:42
Decreased, Triiodothyronine (T3) in tissues November 29, 2016 19:43
Altered, Amphibian metamorphosis December 03, 2016 16:37
Inhibition, Pendrin leads to TH synthesis, Decreased December 03, 2016 16:38

Abstract

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Background (optional)

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Summary of the AOP

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Stressors

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Molecular Initiating Event

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Title Short name
Inhibition, Pendrin Inhibition, Pendrin

Key Events

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Title Short name
Thyroid hormone synthesis, Decreased TH synthesis, Decreased
Decreased, Thyroxine (T4) in serum Decreased, Thyroxine (T4) in serum
Decreased, Thyroxine (T4) in tissues Decreased, Thyroxine (T4) in tissues
Decreased, Triiodothyronine (T3) in tissues Decreased, Triiodothyronine (T3) in tissues

Adverse Outcome

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Title Short name
Altered, Amphibian metamorphosis Altered, Amphibian metamorphosis

Relationships Between Two Key Events (Including MIEs and AOs)

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Title Directness Evidence Quantitative Understanding
Inhibition, Pendrin leads to TH synthesis, Decreased Directly leads to Weak Weak

Network View

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Life Stage Applicability

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Life stage Evidence
Development Strong

Taxonomic Applicability

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Term Scientific Term Evidence Link
African clawed frog Xenopus laevis Weak NCBI

Sex Applicability

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Sex Evidence
Unspecific Strong

Graphical Representation

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Click to download graphical representation template

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Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Weight of Evidence Summary

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Quantitative Considerations

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Considerations for Potential Applications of the AOP (optional)

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References

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