AOP-Wiki

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All Key Events

Showing 1451 to 1475 of 1907 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1944	Synaptic dysfunction Short Name Dysfunctional synapses	2	Organ	Oct 26, 2021	Aug 4, 2025	3 AOPs 429: A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants 475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons 471: Neuron defect induced early behavioral change
1945	Dysfunctional Autophagy Short Name Dysfunctional autophagy	0	Cellular	Oct 26, 2021	Oct 26, 2021	2 AOPs 429: A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants 452: Adverse outcome pathway of PM-induced respiratory toxicity
1946	Impaired mechanotransduction of pericytes Short Name	0	Cellular	Oct 28, 2021	Oct 28, 2021	426: SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction.
1947	Pericyte dysfunction Short Name Pericyte dysfunction	0	Cellular	Oct 28, 2021	Oct 28, 2021	426: SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction.
1948	Increased ACE2 expression Short Name Upregulation of ACE2	0	Molecular	Oct 28, 2021	Oct 28, 2021	426: SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction.
1949	Decrease, GLUT4 Short Name Decrease, GLUT4	0	Cellular	Nov 18, 2021	Nov 18, 2021	431: Increased tumor necrosis factor (TNF) leading to increased risk of gestational diabetes mellitus (GDM)
1950	Increase, TNF Short Name Increase, TNF	0	Molecular	Nov 18, 2021	Nov 18, 2021	431: Increased tumor necrosis factor (TNF) leading to increased risk of gestational diabetes mellitus (GDM)
1951	Decrease, Glucose uptake Short Name Decrease, Glucose uptake	0	Cellular	Nov 18, 2021	Nov 18, 2021	431: Increased tumor necrosis factor (TNF) leading to increased risk of gestational diabetes mellitus (GDM)
1952	Abnormal, Glucose homeostasis Short Name Abnormal, Glucose homeostasis	0	Organ	Nov 18, 2021	Nov 18, 2021	431: Increased tumor necrosis factor (TNF) leading to increased risk of gestational diabetes mellitus (GDM)
1953	Gestational diabetes mellitus Short Name GDM	0	Individual	Nov 18, 2021	Nov 18, 2021	431: Increased tumor necrosis factor (TNF) leading to increased risk of gestational diabetes mellitus (GDM)
1954	Gut microbiota, alteration Short Name Gut dysbiosis	0	Organ	Nov 30, 2021	Jan 4, 2022	428: Binding of S-protein to ACE2 in enterocytes induces ACE2 dysregulation leading to gut dysbiosis
1955	Acute Myeloid Leukemia Short Name AML	0	Individual	Dec 3, 2021	Dec 3, 2021	432: Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia
1956	Binding to hERG channel Short Name Binding to hERG channel	0	Molecular	Dec 13, 2021	Dec 13, 2021	None
1957	hERG channel biogenesis interference Short Name hERG channel biogenesis interference	0	Molecular	Dec 13, 2021	Dec 13, 2021	None
1958	Direct hERG channel blockage Short Name Direct hERG channel blockage	0	Cellular	Dec 13, 2021	Dec 13, 2021	None
1959	Induction of hERG trafficking defects Short Name Induction of hERG trafficking defects	0	Cellular	Dec 13, 2021	Dec 13, 2021	None
1960	Inhibition of Ikr Short Name Inhibition of Ikr	0	Tissue	Dec 13, 2021	Dec 13, 2021	None
1961	Prolongation of Action Potential Duration Short Name Prolongation of Action Potential	0	Organ	Dec 13, 2021	Jan 29, 2023	3 AOPs 433: hERG channel blockade leading to sudden cardiac death 519: Cardiac ion channels blockade leading to increased incidence of cardiovascular morbidity and mortality 555: Inhibition, Ether-a-go-go (ERG) Voltage-Gated Potassium Channel leading to heart failure
1962	Prolongation of QT interval Short Name Prolongation of QT interval	0	Organ	Dec 13, 2021	Dec 13, 2021	3 AOPs 433: hERG channel blockade leading to sudden cardiac death 552: Inhibiton of L-Type Calcium Channels leading to heart failure via QT interval prolongation and Torsades de Pointes (TdP) 555: Inhibition, Ether-a-go-go (ERG) Voltage-Gated Potassium Channel leading to heart failure
1963	Torsades de Pointes Short Name Torsades de Pointes	0	Organ	Dec 13, 2021	Jan 29, 2023	2 AOPs 433: hERG channel blockade leading to sudden cardiac death 552: Inhibiton of L-Type Calcium Channels leading to heart failure via QT interval prolongation and Torsades de Pointes (TdP)
1964	Sudden cardiac death Short Name Sudden cardiac death	0	Individual	Dec 13, 2021	Dec 13, 2021	433: hERG channel blockade leading to sudden cardiac death
1965	Increase, Pollen abnormal Short Name Increase, Pollen abnormal	0	Organ	Jan 13, 2022	Jan 13, 2022	435: Deposition of ionising energy leads to population decline via pollen abnormal
1966	Decrease, Asexual reproduction Short Name Decrease, Asexual reproduction	0	Individual	Jan 17, 2022	Jan 17, 2022	None
1967	Pyroptosis Short Name Pyroptosis	0	Cellular	Jan 18, 2022	Jan 19, 2022	407: SARS-CoV-2 infection leading to pyroptosis
1970	transposition of the great arteries Short Name Transposition of the great arteries	0	Organ	Feb 8, 2022	Feb 15, 2022	436: Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries