AOP-Wiki

API

All Key Events

Showing 1476 to 1500 of 1907 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1971	Increased, tumor growth Short Name tumor growth	1	Organ	Feb 15, 2022	Feb 29, 2024	2 AOPs 439: Activation of the AhR leading to metastatic breast cancer 578: AhR activation leading to cancer progression via immunosuppression
1972	Increased, Steroidogenic acute regulatory protein (StAR) Short Name	4	Cellular	Feb 25, 2022	Mar 1, 2022	440: Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
1973	Increased, estrogens Short Name Increased, estrogens	1	Cellular	Feb 25, 2022	Mar 1, 2022	440: Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
1974	Activation of Tumor Protein 53 Short Name Activation of TP53	0	Cellular	Mar 9, 2022	Mar 17, 2022	441: Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation
1977	Disruption of sodium channel gating kinetics Short Name Altered kinetics of sodium channel	1	Cellular	Mar 15, 2022	Jul 24, 2024	2 AOPs 442: Binding to voltage gate sodium channels during development leads to cognitive impairment 489: Inhibition of voltage-gated sodium channels leading to decreased cognition
1978	Increase risk, microcephaly Short Name Microcephaly	0	Individual	Mar 17, 2022	Mar 18, 2022	2 AOPs 441: Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation 523: Retinoic acid receptor agonism during neurodevelopment leading to microcephaly
1979	Premature cell differentiation Short Name Premature differentiation	0	Organ	Mar 21, 2022	Mar 21, 2022	441: Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation
1980	Increased microRNA expression Short Name Increase,miRNA levels	0	Cellular	Mar 22, 2022	Aug 27, 2023	443: DNA damage and mutations leading to Metastatic Breast Cancer
1981	Decreased SIRT1 expression Short Name Decrease,SIRT1(sirtuin 1) levels	0	Cellular	Mar 22, 2022	Mar 24, 2022	443: DNA damage and mutations leading to Metastatic Breast Cancer
1982	metastatic breast cancer Short Name Metastasis, Breast Cancer	0	Organ	Mar 22, 2022	May 14, 2024	2 AOPs 443: DNA damage and mutations leading to Metastatic Breast Cancer 439: Activation of the AhR leading to metastatic breast cancer
1983	Disruption, action potential generation Short Name	1	Cellular	Mar 31, 2022	Jul 24, 2024	2 AOPs 442: Binding to voltage gate sodium channels during development leads to cognitive impairment 551: Increased Muscarinic M2 Receptor leading to Arrhythmia
1984	Agonism, Estrogen Receptor alpha Short Name Agonism, Estrogen Receptor alpha	0	Molecular	Apr 5, 2022	Apr 5, 2022	None
1985	Increased Kisspeptin levels in anteroventral periventricular nucleus (AVPV) Short Name Increased Kisspeptin levels in AVPV	1	Cellular	Apr 5, 2022	Jan 29, 2026	2 AOPs 445: Estrogen Receptor Alpha Agonism leads to Impaired Reproduction 623: Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release
1986	Decreased, Gonadotropins Short Name Decreased, Gonadotropins	1	Tissue	Apr 5, 2022	Jan 28, 2026	2 AOPs 445: Estrogen Receptor Alpha Agonism leads to Impaired Reproduction 609: Activation, estrogen receptor alpha leads to prolonged estrus cycle via decreased kisspeptin release
1987	Decreased, Androgen and Progestin Short Name Decreased , Androgen and Progestin	0	Cellular	Apr 5, 2022	Jun 6, 2022	445: Estrogen Receptor Alpha Agonism leads to Impaired Reproduction
1988	Decreased, Maturation Inducing Steroid Surge by Granulosa cells Short Name	0	Tissue	Apr 5, 2022	Apr 5, 2022	445: Estrogen Receptor Alpha Agonism leads to Impaired Reproduction
1989	Impaired, Oocyte maturation and ovulation Short Name	0	Tissue	Apr 5, 2022	Apr 5, 2022	445: Estrogen Receptor Alpha Agonism leads to Impaired Reproduction
1990	Increased, Oocyte Atresia Short Name Increased, Oocyte Atresia	0	Tissue	Apr 5, 2022	Apr 5, 2022	445: Estrogen Receptor Alpha Agonism leads to Impaired Reproduction
1991	Impaired, Reproduction Short Name Impaired, Reproduction	0	Population	Apr 5, 2022	Apr 5, 2022	445: Estrogen Receptor Alpha Agonism leads to Impaired Reproduction
1992	Increased incidence of respiratory morbidity and mortality in the general population Short Name	0	Population	Apr 7, 2022	Apr 7, 2022	None
1993	Increase, Pneumonia Short Name Pneumonia	0	Organ	Apr 7, 2022	Apr 7, 2022	None
1994	Increase, Ferroptosis Short Name Ferroptosis	0	Cellular	Apr 7, 2022	Apr 7, 2022	615: Suppression of Keap1 cysteine oxidation leading to liver inflammation
1995	Abnormal lipid metabolism Short Name Abnormal lipid metabolism	0	Cellular	Apr 7, 2022	Apr 7, 2022	401: G protein-coupled estrogen receptor 1 (GPER) signal pathway in the lipid metabolism disrupting effects
1996	Increased incidence of digestive morbidity and mortality in the general population Short Name	0	Population	Apr 7, 2022	Apr 7, 2022	None
1997	Colon epithelial injury Short Name Colon epithelial injury	0	Organ	Apr 7, 2022	Apr 7, 2022	None