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Showing 1826 to 1850 of 1907 Key Events

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ID Title Event Component Count Biological Organization Created At Last Updated AOPs
2329 Sine oculis homeobox 1 gene expression, increased
1 Molecular Jul 8, 2025 Sep 11, 2025 167: Early-life estrogen receptor agonism leading to endometrial adenosquamous carcinoma via promotion of sine oculis homeobox 1 progenitor cells
2330 Sine oculis homeobox 1 protein expression, increased
1 Molecular Jul 8, 2025 Dec 17, 2025 167: Early-life estrogen receptor agonism leading to endometrial adenosquamous carcinoma via promotion of sine oculis homeobox 1 progenitor cells
2331 Activation, Mineralocorticoid Receptor
0 Molecular Jul 25, 2025 Jul 25, 2025 580: Mineralocorticoid Receptor Activation Leading to Increased Body Mass Index
2332 Increase, Lipid droplet
0 Cellular Jul 25, 2025 Jul 25, 2025 580: Mineralocorticoid Receptor Activation Leading to Increased Body Mass Index
2333 Increase, Fat mass
0 Organ Jul 25, 2025 Jul 25, 2025 580: Mineralocorticoid Receptor Activation Leading to Increased Body Mass Index
2334 Increase, DGAT1
0 Molecular Jul 25, 2025 Jul 25, 2025 580: Mineralocorticoid Receptor Activation Leading to Increased Body Mass Index
2335 Increase, body mass index
0 Individual Jul 25, 2025 Jul 25, 2025 580: Mineralocorticoid Receptor Activation Leading to Increased Body Mass Index
2336 Increase, SREBF1
0 Molecular Jul 25, 2025 Jul 25, 2025 580: Mineralocorticoid Receptor Activation Leading to Increased Body Mass Index
2337 Increase, perilipin-2
0 Molecular Jul 25, 2025 Jul 25, 2025 580: Mineralocorticoid Receptor Activation Leading to Increased Body Mass Index
2339 Intracellular copper, increased
0 Cellular Aug 13, 2025 Oct 16, 2025 590: Increase of intracellular copper leading to cuproptosis via interference with energy metabolism
2340 Oligomerisation of dihydrolipoamide acetyltransferase (DLAT), increased
0 Molecular Aug 13, 2025 Oct 16, 2025 590: Increase of intracellular copper leading to cuproptosis via interference with energy metabolism
2341 Tricarboxylic acid (TCA) cycle, disrupted
0 Molecular Aug 13, 2025 Oct 16, 2025 590: Increase of intracellular copper leading to cuproptosis via interference with energy metabolism
2342 Iron-sulfur cluster assembly, impaired
0 Molecular Aug 13, 2025 Oct 30, 2025 590: Increase of intracellular copper leading to cuproptosis via interference with energy metabolism
2343 Cuproptosis, increased
0 Cellular Aug 13, 2025 Oct 16, 2025 590: Increase of intracellular copper leading to cuproptosis via interference with energy metabolism
2344 Upregulation, growth arrest and DNA-damage-inducible beta a
0 Molecular Aug 16, 2025 Aug 16, 2025 591: DBDPE-induced DNA damage increase in liver leading to Non-alcoholic fatty liver disease via liver steatosis and inhibition of regeneration
2345 Activation, MAPK
0 Molecular Aug 16, 2025 Aug 16, 2025 591: DBDPE-induced DNA damage increase in liver leading to Non-alcoholic fatty liver disease via liver steatosis and inhibition of regeneration
2346 Decrease, Proliferating Cell Nuclear Antigen
0 Molecular Aug 16, 2025 Aug 16, 2025 591: DBDPE-induced DNA damage increase in liver leading to Non-alcoholic fatty liver disease via liver steatosis and inhibition of regeneration
2347 Increase, Lipid degradation
0 Cellular Aug 16, 2025 Aug 16, 2025 591: DBDPE-induced DNA damage increase in liver leading to Non-alcoholic fatty liver disease via liver steatosis and inhibition of regeneration
2348 Inhibition, Liver regeneration
0 Organ Aug 16, 2025 Aug 16, 2025 591: DBDPE-induced DNA damage increase in liver leading to Non-alcoholic fatty liver disease via liver steatosis and inhibition of regeneration
2349 Inhibition of LDH activity
0 Molecular Aug 16, 2025 Aug 16, 2025 592: DBDPE-induced DNA strand breaks and LDH activity inhibition leading to population growth rate decline via energy metabolism disrupt and apoptosis
2350 Decreased, Glycolysis
0 Cellular Aug 16, 2025 Aug 16, 2025 592: DBDPE-induced DNA strand breaks and LDH activity inhibition leading to population growth rate decline via energy metabolism disrupt and apoptosis
2351 Increased, OXPHOS
0 Cellular Aug 16, 2025 Aug 16, 2025 592: DBDPE-induced DNA strand breaks and LDH activity inhibition leading to population growth rate decline via energy metabolism disrupt and apoptosis
2352 Increased, MMP
0 Cellular Aug 16, 2025 Aug 16, 2025 592: DBDPE-induced DNA strand breaks and LDH activity inhibition leading to population growth rate decline via energy metabolism disrupt and apoptosis
2353 Disrupted, energy metabolism
0 Cellular Aug 16, 2025 Aug 16, 2025 592: DBDPE-induced DNA strand breaks and LDH activity inhibition leading to population growth rate decline via energy metabolism disrupt and apoptosis
2354 Activation, Apoptosis signaling
0 Cellular Aug 16, 2025 Aug 16, 2025 592: DBDPE-induced DNA strand breaks and LDH activity inhibition leading to population growth rate decline via energy metabolism disrupt and apoptosis