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All Key Events

Showing 451 to 475 of 1939 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1988	Decreased, Maturation Inducing Steroid Surge by Granulosa cells Short Name	0	Tissue	Apr 5, 2022	Apr 5, 2022	445: Estrogen Receptor Alpha Agonism leads to Impaired Reproduction
1987	Decreased, Androgen and Progestin Short Name Decreased , Androgen and Progestin	0	Cellular	Apr 5, 2022	Jun 6, 2022	445: Estrogen Receptor Alpha Agonism leads to Impaired Reproduction
1986	Decreased, Gonadotropins Short Name Decreased, Gonadotropins	1	Tissue	Apr 5, 2022	Apr 6, 2026	2 AOPs 445: Estrogen Receptor Alpha Agonism leads to Impaired Reproduction 609: Activation, estrogen receptor alpha leads to prolonged estrus cycle via decreased kisspeptin release
1985	Increased Kisspeptin levels in anteroventral periventricular nucleus (AVPV) Short Name Increased Kisspeptin levels in AVPV	1	Cellular	Apr 5, 2022	Apr 6, 2026	5 AOPs 445: Estrogen Receptor Alpha Agonism leads to Impaired Reproduction 623: Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release 637: Activation, estrogen receptor alpha leads to increased uterine weight via earlier proliferation of cells of the uterine lining 639: Activation, estrogen receptor alpha leads to precocious puberty via increased kisspeptin release 640: Activation, estrogen receptor alpha leads to decreased fertility via prolonged estrus cycle
1984	Agonism, Estrogen Receptor alpha Short Name Agonism, Estrogen Receptor alpha	0	Molecular	Apr 5, 2022	Apr 5, 2022	None
1983	Disruption, action potential generation Short Name	1	Cellular	Mar 31, 2022	Jul 24, 2024	2 AOPs 442: Binding to voltage gate sodium channels during development leads to cognitive impairment 551: Increased Muscarinic M2 Receptor leading to Arrhythmia
1982	metastatic breast cancer Short Name Metastasis, Breast Cancer	0	Organ	Mar 22, 2022	May 14, 2024	2 AOPs 443: DNA damage and mutations leading to Metastatic Breast Cancer 439: Activation of the AhR leading to metastatic breast cancer
1981	Decreased SIRT1 expression Short Name Decrease,SIRT1(sirtuin 1) levels	0	Cellular	Mar 22, 2022	Mar 24, 2022	443: DNA damage and mutations leading to Metastatic Breast Cancer
1980	Increased microRNA expression Short Name Increase,miRNA levels	0	Cellular	Mar 22, 2022	Aug 27, 2023	443: DNA damage and mutations leading to Metastatic Breast Cancer
1979	Premature cell differentiation Short Name Premature differentiation	0	Organ	Mar 21, 2022	Mar 21, 2022	441: Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation
1978	Increase risk, microcephaly Short Name Microcephaly	0	Individual	Mar 17, 2022	Mar 18, 2022	2 AOPs 441: Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation 523: Retinoic acid receptor agonism during neurodevelopment leading to microcephaly
1977	Disruption of sodium channel gating kinetics Short Name Altered kinetics of sodium channel	1	Cellular	Mar 15, 2022	Jul 24, 2024	2 AOPs 442: Binding to voltage gate sodium channels during development leads to cognitive impairment 489: Inhibition of voltage-gated sodium channels leading to decreased cognition
1974	Activation of Tumor Protein 53 Short Name Activation of TP53	0	Cellular	Mar 9, 2022	Mar 17, 2022	441: Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation
1973	Increased, estrogens Short Name Increased, estrogens	1	Cellular	Feb 25, 2022	Mar 1, 2022	440: Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
1972	Increased, Steroidogenic acute regulatory protein (StAR) Short Name	4	Cellular	Feb 25, 2022	Mar 1, 2022	440: Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
1971	Increased, tumor growth Short Name tumor growth	1	Organ	Feb 15, 2022	Feb 29, 2024	2 AOPs 439: Activation of the AhR leading to metastatic breast cancer 578: AhR activation leading to cancer progression via immunosuppression
1970	transposition of the great arteries Short Name Transposition of the great arteries	0	Organ	Feb 8, 2022	Feb 15, 2022	436: Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
1967	Pyroptosis Short Name Pyroptosis	0	Cellular	Jan 18, 2022	Jan 19, 2022	2 AOPs 407: SARS-CoV-2 infection leading to pyroptosis 638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis
1966	Decrease, Asexual reproduction Short Name Decrease, Asexual reproduction	0	Individual	Jan 17, 2022	Jan 17, 2022	None
1965	Increase, Pollen abnormal Short Name Increase, Pollen abnormal	0	Organ	Jan 13, 2022	Jan 13, 2022	435: Deposition of ionising energy leads to population decline via pollen abnormal
1964	Sudden cardiac death Short Name Sudden cardiac death	0	Individual	Dec 13, 2021	Dec 13, 2021	433: hERG channel blockade leading to sudden cardiac death
1963	Torsades de Pointes Short Name Torsades de Pointes	0	Organ	Dec 13, 2021	Jan 29, 2023	2 AOPs 433: hERG channel blockade leading to sudden cardiac death 552: Inhibiton of L-Type Calcium Channels leading to heart failure via QT interval prolongation and Torsades de Pointes (TdP)
1962	Prolongation of QT interval Short Name Prolongation of QT interval	0	Organ	Dec 13, 2021	Dec 13, 2021	3 AOPs 433: hERG channel blockade leading to sudden cardiac death 552: Inhibiton of L-Type Calcium Channels leading to heart failure via QT interval prolongation and Torsades de Pointes (TdP) 555: Inhibition, Ether-a-go-go (ERG) Voltage-Gated Potassium Channel leading to heart failure
1961	Prolongation of Action Potential Duration Short Name Prolongation of Action Potential	0	Organ	Dec 13, 2021	Jan 29, 2023	3 AOPs 433: hERG channel blockade leading to sudden cardiac death 519: Cardiac ion channels blockade leading to increased incidence of cardiovascular morbidity and mortality 555: Inhibition, Ether-a-go-go (ERG) Voltage-Gated Potassium Channel leading to heart failure
1960	Inhibition of Ikr Short Name Inhibition of Ikr	0	Tissue	Dec 13, 2021	Dec 13, 2021	None