API

Stressor: 282

Title

?

Ketoconazole

Stressor Overview

?


AOPs Including This Stressor

?


Events Including This Stressor

?


Chemical Table

?

User term DTXID Preferred name Casrn jchem_inchi_key indigo_inchi_key
Ketoconazole DTXSID7029879 Ketoconazole 65277-42-1 XMAYWYJOQHXEEK-OZXSUGGESA-N XMAYWYJOQHXEEK-OZXSUGGESA-N

AOP Evidence

?


Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity

Conazole is a class of fungicide that inhibits CYP51 14α-lanosterol demethylase activity in yeats and moults, thereby preventing ergosterol synthesis (Hof et al., 2006). In animals, conazoles are known to be less specific than in fungi since they can interfere with various cytochromes P450 activity.  For instance, it is clearly demonstrated that ketoconazole directly inhibits CYP7B activity which induces a decrease in 7α-hydroxypregnenolone (Matsunaga et al., 2004, Tsutsui et al., 2008; Toyoda et al., 2012; Ogura et al., 2016).



Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior

There is no evidence text for this AOP




Event Evidence

?


CYP7B activity, inhibition

It is clearly demonstrated that ketoconazole directly inhibits CYP7B (Matsunaga et al., 2004). It is expected for the other members of the conazole family to have the same effect.

Some other azoles such as clotrimazole can also inhibit CYP7B activity (Liu et al., 2011; Rose et al., 1997). 



7α-hydroxypregnenolone synthesis in the brain, decreased

There is no evidence text for this event.




Stressor Info

?



Chemical/Category Description

?

Instructions

To edit the “ Stressor Description” section, on a KER page, in the upper right hand menu, click ‘Edit.’ This brings you to a page entitled, “Editing Stressor.”  Scroll down to the “Stressor Description” section, where a text entry box allows you to submit text. Click ‘Update’ to save your changes and return to the Stressor page.  The new text should appear under the “Stressor Description”  section on the page.



Characterization of Exposure

?

Instructions

To edit the “Characterization of Exposure” section, on a Stressor page, in the upper right hand menu, click ‘Edit.’ This brings you to a page entitled, “Editing Stressor.”  Scroll down to the “Characterization of Exposure”  section, where a text entry box allows you to submit text. Click ‘Update’ to save your changes and return to the Stressor page.  The new text should appear under the “Characterization of Exposure” section on the page.



References

?


List the bibliographic references to original papers, books or other documents used to support the Stressor.

Instructions

To edit the “References” section, on a Stressor page, in the upper right hand menu, click ‘Edit.’ This brings you to a page entitled, “Editing Stressor.”  Scroll down to the “References” section, where a text entry box allows you to submit text. Click ‘Update’ to save your changes and return to the Stressor page.  The new text should appear under the “References” section on the page.