Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 376 to 400 of 1139 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
376 increased preneoplasia (MP:0002009) abnormal cell mass (MP:0003902) 774: Increase, Preneoplastic foci (hepatocytes)
377 abnormal regulation of gene expression (GO:0010468) 1214: Altered gene expression specific to CAR activation, Hepatocytes
378 increased cellular respiration (GO:0045333) 769: Increase, Oxidative metabolism
379 increased pyruvate dehydrogenase activity (GO:0004738) pyruvate dehydrogenase [ubiquinone] (PR:000023575) 726: Increased, Induction of pyruvate dehydrogenase (PDH)
380 decreased pyruvate dehydrogenase activity (GO:0004738) Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (rat) (PR:Q63065) 724: Inhibition, Pyruvate dehydrogenase kinase (PDK) enzyme
381 increased cell death (GO:0008219) bronchial epithelial cell (CL:0002328) 733: Increase, Necrosis (terminal bronchiolar cells)
382 increased epithelial cell proliferation (GO:0050673) bronchial epithelial cell (CL:0002328) 734: Increase, Regenerative cell proliferation (terminal bronchiolar epithelial cells)
383 increased hyperplasia (MESH:D006965) bronchial epithelial cell (CL:0002328) 735: Increase, Hyperplasia (terminal bronchiolar cells)
384 increased cell death (GO:0008219) Clara cell (CL:0000158) 770: Increase, Cytotoxicity (club cells)
385 increased cell proliferation (GO:0008283) thyroid follicular cell (CL:0002258)
386 increased hypertrophy (MESH:D006984) thyroid follicular cell (CL:0002258)
387 increased hyperplasia (MESH:D006965) thyroid follicular cell (CL:0002258)
388 increased Thyroid stimulating hormone (CHEBI:81567)
389 decreased receptor binding (GO:0005102) testosterone (CHEBI:17347) 743: Decreased, Testosterone binding to androgen receptor (hypothalamus)
390 increased Leydig cell hyperplasia (MP:0001152) Leydig cell (CL:0000178) 744: Increase, Hyperplasia (Leydig cells)
391 increased neoplasm (MP:0002006) 745: Increase, Leydig cell tumors
392 increased Luteinizing hormone (CHEBI:81568)
393 decreased Prolactin (CHEBI:81580) 747: Decreased, Prolactin
394 decreased progesterone secretion (GO:0042701) progesterone (CHEBI:17026) 749: Decreased, Progesterone from corpus luteum
395 increased synaptic transmission, dopaminergic (GO:0001963) 746: Increase, Dopaminergic activity
396 increased endometrium hyperplasia (MP:0009092) glandular cell of endometrium (CL:0002656) 772: Increase, Hyperplasia (glandular epithelial cells of endometrium)
397 increased chloride channel activity (GO:0005254) glutamate-gated chloride channel (fruit fly) (PR:Q94900)
398 decreased population quality (PCO:0000003) 765: Decreased, population 1
399 increased chloride transmembrane transport (GO:1902476) chloride (CHEBI:17996) 761: Increased, Chloride conductance
400 increased membrane hyperpolarization (GO:0060081) 763: hyperpolarisation, neuron