Key Event Components

Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
A complete list of all KECs is available in TSV format on the Downloads Page.

Showing 501 to 525 of 1139 KECs

ID	Action	Process	Object	Associated Key Events (KEs)


501	decreased	protein dimerization activity (GO:0046983)	hypoxia-inducible factor 1-alpha (PR:000008555)	945: reduced dimerization, ARNT/HIF1-alpha
502	decreased	protein dimerization activity (GO:0046983)	aryl hydrocarbon receptor nuclear translocator (PR:000004303)	945: reduced dimerization, ARNT/HIF1-alpha
503	increased	binding (GO:0005488)	transthyretin (PR:000016801)	957: Binding, Transthyretin in serum
504	increased		thyroxine (CHEBI:30660)	3 Events 959: Increased, Free serum thyroxine (T4) 1093: Decreased, Thyroxine (T4) in tissues 958: Displacement, Serum thyroxine (T4) from transthyretin
505	increased	transport (GO:0006810)	thyroxine (CHEBI:30660)	960: Increased, Uptake of thyroxine into tissue
506	increased	metabolic process (GO:0008152)	thyroxine (CHEBI:30660)	961: Increased, Clearance of thyroxine from serum
507	decreased	signaling (GO:0023052)	aromatase (PR:000006100)	964: Inhibition of Aromatase Enzyme, Chemical exposure during critical window of estrous cycle between diestrus 2 and proestrus inhibits aromatase conversion of testosterone to estradiol
508	decreased		estrogen (CHEBI:50114)	None
509	decreased	neurotransmitter secretion (GO:0007269)	metastasis-suppressor KiSS-1 (rat) (PR:Q7TSB7)	None
510	decreased	luteinizing hormone secretion (GO:0032275)	Luteinizing hormone (CHEBI:81568)	2 Events 970: Decreased LH release from Anterior Pituitary, Decreased GnRH stimulation of Anterior Pituitary Gonadotrophs 1050: Increased, secretion of LH from anterior pituitary
511	abnormal	ovulation cycle (GO:0042698)		971: Ovulation of oocytes Reduced, Delayed, or Blocked, Decrease or delay in LH surge required for ovulation
512	increased	genetic interference (MI:0254)	NFAT protein (PR:000003112)	979: Interference, nuclear localization of NFAT
513	decreased	cytokine production involved in inflammatory response (GO:0002534)	NFAT activation molecule 1 (PR:000011161)	981: Reduction, NFAT/AP-1 complex formation
514	increased	Immunosuppression (MESH:D007165)		None
515	increased	binding (GO:0005488)	FK506-binding protein 15 (PR:000007535)	980: Inhibition, Calcineurin Activity
516	increased	binding (GO:0005488)	FKBP12 (Arabidopsis thaliana) (TAIR:AT5G64350)	980: Inhibition, Calcineurin Activity
517	increased	binding (GO:0005488)	Immunophilins (MESH:D020104)	1201: Binding, Immunophilins
518	decreased	interleukin-2 production (GO:0032623)	interleukin-2 (PR:000001379)	1202: Suppression, IL-2 and IL-4 production
519	decreased	interleukin-4 production (GO:0032633)	interleukin-4 (PR:000001391)	2 Events 1202: Suppression, IL-2 and IL-4 production 1718: Suppression of IL-4 production
520	decreased		3,3',5-triiodo-L-thyronine (CHEBI:18258)	2 Events 1116: Decreased, Triiodothyronine (T3) in tissues 1154: Increased, Triiodothyronine (T3) in tissues
521	decreased	catalytic activity (GO:0003824)	type II iodothyronine deiodinase (PR:000006481)	1002: Inhibition, Deiodinase 2
522	decreased	swim bladder inflation (GO:0048798)	posterior chamber swim bladder (UBERON:2001278)	1004: Reduced, Posterior swim bladder inflation
523	decreased	survival (MESH:D013534)		None
524	decreased	swim bladder inflation (GO:0048798)	anterior chamber swim bladder (UBERON:2001277)	1007: Reduced, Anterior swim bladder inflation
525	decreased	sensory perception of sound (GO:0007605)		1008: Reduced, Hearing