Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 601 to 625 of 1139 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
601 abnormal post-translational protein modification (GO:0043687) osteocalcin (PR:000030444) 1169: Anticoagulant rodenticide interferes with carboxylation of Gla proteins in bone, Impairment of post-translational modification (carboxylation) of osteocalcin
602 decreased carboxylation reaction (MI:1139) matrix Gla protein (mouse) (PR:P19788) 1169: Anticoagulant rodenticide interferes with carboxylation of Gla proteins in bone, Impairment of post-translational modification (carboxylation) of osteocalcin
603 decreased catalytic activity (GO:0003824) iodotyrosine deiodinase 1 (human) (PR:Q6PHW0) 1152: Inhibition, Iodotyrosine deiodinase (IYD)
604 decreased catalytic activity (GO:0003824) type III iodothyronine deiodinase (PR:000006482) 1153: Inhibition, Deiodinase 3
605 decreased signaling (GO:0023052) pendrin (PR:000015039) 1155: Inhibition, Pendrin
606 decreased catalytic activity (GO:0003824) dual oxidase 1 (PR:000006727) 1156: Inhibition, Dual oxidase
607 increased signaling (GO:0023052) protein (PR:000000001) 1157: Activation, Hepatic nuclear receptor(s)
608 increased transport (GO:0006810) thyroid hormone (CHEBI:60311) 1158: Increased, Hepatic thyroid hormone uptake/transport
609 increased catalytic activity (GO:0003824) beta-1,3-glucuronyltransferase (PR:000001325) 295: Induction, Upregulation of glucuronyltransferase activity
610 increased cell maturation (GO:0048469) gamete (CL:0000300) 1161: Increased, oocyte maturation
611 increased reproductive process (GO:0022414) 1163: Increased, Reproductive Success
612 increased population of organisms (PCO:0000001) 1164: Increased, Population
613 premature spawning (MESH:C82476) 1255: induced spawning
614 increased signaling (GO:0023052) transient receptor potential cation channel TRPV1 (PR:000001065)
615 increased calcium ion transport (GO:0006816) calcium ion (CHEBI:39124)
616 decreased rhythmic excitation (GO:0043179) vagus nerve (UBERON:0001759) 1220: Trigeminal nerve activation
617 increased neuropeptide hormone activity (GO:0005184) Substance P (CHEBI:80308) 1222: SP (Substance P) release, Local increase of SP
618 increased reflex (GO:0060004) trigeminal nerve (UBERON:0001645) 1223: Trigeminal and/or vagal nerve excitation causes Airway Hyper-responsiveness,Cough, Dyspnea
619 increased cough (MESH:D003371)
620 increased Respiratory Hypersensitivity (MESH:D012130) 1223: Trigeminal and/or vagal nerve excitation causes Airway Hyper-responsiveness,Cough, Dyspnea
621 increased Dyspnea (MESH:D004417) 1223: Trigeminal and/or vagal nerve excitation causes Airway Hyper-responsiveness,Cough, Dyspnea
622 increased dermatitis (MP:0001194)
623 increased cytokine production (GO:0001816) tumor necrosis factor alpha (PR:000000134) 1224: Non-neuronal production of TNF, Epithelial irritation
624 increased abnormal acute inflammation (MP:0002498) 1225: Immune system inflammation
625 increased inflammatory response (GO:0006954) respiratory system (UBERON:0001004) 1226: Increased Respiratory irritability and Chronic Cough,