Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 726 to 750 of 1141 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
416 decreased catalytic activity (GO:0003824) iodotyrosine deiodinase 1 (mouse) (PR:Q9DCX8) 788: Decrease, Incorporation of active iodide into iodotyrosines
415 increased cell proliferation (GO:0008283) hepatocyte (CL:0000182) 787: Increase, Regenerative cell proliferation (hepatocytes)
414 increased cell death (GO:0008219) hepatocyte (CL:0000182) 786: Increase, Cytotoxicity (hepatocytes)
413 increased hepatocellular carcinoma (MESH:D006528) Adenoma (MESH:D000236) 719: Increase, hepatocellular adenomas and carcinomas
412 increased kidney epithelium hyperplasia (MP:0004968) nephron tubule epithelial cell (CL:1000494) 784: Increase, Hyperplasia (tubular epithelial cells)
411 increased cell death (GO:0008219) nephron tubule epithelial cell (CL:1000494) 783: Increase, Cytotoxicity (tubular epithelial cells)
410 increased Carcinoma, Renal Cell (MESH:D002292) Adenoma (MESH:D000236) 713: Increase, Adenomas/carcinomas (renal tubular)
409 increased stomach epithelial hyperplasia (MP:0005493) epithelial cell (CL:0000066) 782: Increase, Hyperplasia (forestomach epithelial cells)
408 increased cell proliferation (GO:0008283) epithelial cell (CL:0000066)
407 increased cell death (GO:0008219) epithelial cell (CL:0000066) 780: Increase, Cytotoxicity (epithelial cells)
406 decreased 4-hydroxyphenylpyruvate dioxygenase activity (GO:0003868) 4-hydroxyphenylpyruvate dioxygenase (rat) (PR:P32755) 766: Inhibition, 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) enzyme
405 increased tyrosine (CHEBI:18186) 775: Increased, Plasma tyrosine
404 increased papilloma (MESH:D010212) 779: Increase, Papillomas/carcinomas (squamous cells)
403 increased cell proliferation (GO:0008283) corneal epithelial cell (CL:0000575) 778: Increase, Regenerative cell proliferation (corneal cells)
402 increased inflammatory response (GO:0006954) corneal epithelial cell (CL:0000575) 777: Increase, Inflammation (corneal cells)
401 increased cell death (GO:0008219) corneal epithelial cell (CL:0000575) 776: Increase, Cytotoxicity (corneal cells)
400 increased membrane hyperpolarization (GO:0060081) 763: hyperpolarisation, neuron
399 increased chloride transmembrane transport (GO:1902476) chloride (CHEBI:17996) 761: Increased, Chloride conductance
398 decreased population quality (PCO:0000003) 765: Decreased, population 1
397 increased chloride channel activity (GO:0005254) glutamate-gated chloride channel (fruit fly) (PR:Q94900)
396 increased endometrium hyperplasia (MP:0009092) glandular cell of endometrium (CL:0002656) 772: Increase, Hyperplasia (glandular epithelial cells of endometrium)
395 increased synaptic transmission, dopaminergic (GO:0001963) 746: Increase, Dopaminergic activity
394 decreased progesterone secretion (GO:0042701) progesterone (CHEBI:17026) 749: Decreased, Progesterone from corpus luteum
393 decreased Prolactin (CHEBI:81580) 747: Decreased, Prolactin
392 increased Luteinizing hormone (CHEBI:81568)