Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 1101 to 1125 of 1145 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
45 increased cochlear degeneration (MP:0000032) 319: Loss, Cochlear function
44 abnormal chemical synaptic transmission (GO:0007268) None
43 morphological change hippocampal formation (UBERON:0002421) None
42 abnormal regulation of gene expression (GO:0010468) hippocampal formation (UBERON:0002421) 756: Hippocampal gene expression, Altered
41 decreased thyroxine (CHEBI:30660)
40 increased excretion (GO:0007588) Tetrahydroaldosterone-3-glucuronide (CHEBI:88728) 401: Increase, Biliary excretion TH glucuronide
39 increased glucuronosyltransferase activity (GO:0015020) beta-1,3-glucuronyltransferase (PR:000001325) 295: Induction, Upregulation of glucuronyltransferase activity
38 increased signaling (GO:0023052) nuclear receptor subfamily 1 group I member 3 (PR:000011398) 715: Activation, Constitutive androstane receptor
37 increased signaling (GO:0023052) nuclear receptor subfamily 1 group I member 2 (PR:000011397)
36 disrupted ovulation cycle (GO:0042698) None
35 decreased fertility (MESH:D005298) 406: decreased, Fertility
34 decreased estrogen biosynthetic process (GO:0006703) 17beta-estradiol (CHEBI:16469)
33 decreased 17beta-estradiol (CHEBI:16469)
32 decreased aromatase activity (GO:0070330) aromatase (PR:000006100)
31 decreased weight loss (MP:0001263) None
30 increased protein catabolic process (GO:0030163) muscle protein (MESH:D009124) 863: Increased, Catabolism of Muscle Protein
29 abnormal ketone body (CHEBI:73693) 862: Not Increased, Circulating Ketone Bodies
28 abnormal abnormal lipid homeostasis (MP:0002118) 862: Not Increased, Circulating Ketone Bodies
27 decreased ketosis (MESH:D007662)
26 decreased fatty acid beta-oxidation (GO:0006635) fatty acid (CHEBI:35366)
25 decreased receptor transactivation (GO:0035624) peroxisome proliferator-activated receptor alpha (PR:000013056) 858: Decreased, PPARalpha transactivation of gene expression
24 increased transcription corepressor activity (GO:0003714) nuclear receptor corepressor 1 (PR:000011047) 1000: stabilization, PPAR alpha co-repressor
23 increased transcription corepressor activity (GO:0003714) nuclear receptor corepressor 2 (PR:000011048) 1000: stabilization, PPAR alpha co-repressor
22 increased receptor antagonist activity (GO:0048019) peroxisome proliferator-activated receptor alpha (PR:000013056) 998: Binding of antagonist, PPAR alpha
21 decreased excitatory postsynaptic potential (GO:0060079) 1268: Decrease, Excitatory postsynaptic potential