Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 526 to 550 of 1159 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
634 increased oxidation-reduction process (GO:0055114) deoxyribonucleic acid (CHEBI:16991) 1238: Activation of oxidative stress pathway
633 increased oxidation-reduction process (GO:0055114) protein (PR:000000001) 1238: Activation of oxidative stress pathway
632 increased oxidation-reduction process (GO:0055114) plasma membrane (GO:0005886) 1238: Activation of oxidative stress pathway
631 increased reflex (GO:0060004) sneezing (MESH:D012912) 1434: Irritation of nasal mucosa inducing sneeze reflex
630 increased immune response (GO:0006955) 1237: Sensitization, Immune system
629 increased antigen processing and presentation (GO:0019882) hapten (CHEBI:59174) 1236: Generation of novel epitopes , Antigen presentation
628 increased regulation of chemokine (C-X-C motif) ligand 1 production (GO:2000338) growth-regulated alpha protein (PR:000006063) 1235: Non-neuronal production of IL-8/CXCL1, Epithelial irritation
627 increased cytokine production (GO:0001816) interleukin-8 (PR:000001395) 1235: Non-neuronal production of IL-8/CXCL1, Epithelial irritation
626 increased cytokine production (GO:0001816) beta-nerve growth factor (PR:000011194) 1234: Production of nerve growth factor , Epithelial irritation
625 increased inflammatory response (GO:0006954) respiratory system (UBERON:0001004) 1226: Increased Respiratory irritability and Chronic Cough,
624 increased abnormal acute inflammation (MP:0002498) 1225: Immune system inflammation
623 increased cytokine production (GO:0001816) tumor necrosis factor alpha (PR:000000134) 1224: Non-neuronal production of TNF, Epithelial irritation
622 increased dermatitis (MP:0001194)
621 increased Dyspnea (MESH:D004417) 1223: Trigeminal and/or vagal nerve excitation causes Airway Hyper-responsiveness,Cough, Dyspnea
620 increased Respiratory Hypersensitivity (MESH:D012130) 1223: Trigeminal and/or vagal nerve excitation causes Airway Hyper-responsiveness,Cough, Dyspnea
619 increased cough (MESH:D003371)
618 increased reflex (GO:0060004) trigeminal nerve (UBERON:0001645) 1223: Trigeminal and/or vagal nerve excitation causes Airway Hyper-responsiveness,Cough, Dyspnea
617 increased neuropeptide hormone activity (GO:0005184) Substance P (CHEBI:80308) 1222: SP (Substance P) release, Local increase of SP
616 decreased rhythmic excitation (GO:0043179) vagus nerve (UBERON:0001759) 1220: Trigeminal nerve activation
615 increased calcium ion transport (GO:0006816) calcium ion (CHEBI:39124)
614 increased signaling (GO:0023052) transient receptor potential cation channel TRPV1 (PR:000001065)
613 premature spawning (MESH:C82476) 1255: induced spawning
612 increased population of organisms (PCO:0000001) 1164: Increased, Population
611 increased reproductive process (GO:0022414) 1163: Increased, Reproductive Success
610 increased cell maturation (GO:0048469) gamete (CL:0000300) 1161: Increased, oocyte maturation