Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 726 to 750 of 1159 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
434 decreased norepinephrine binding (GO:0051380) (R)-noradrenaline (CHEBI:18357) 848: Decreased, Binding of NE to NE receptors on GnRH neurons
433 decreased hormone secretion (GO:0046879) Luteinizing hormone (CHEBI:81568)
432 decreased reduced fertility (MP:0001921) fertility (MESH:D005298) 527: Decreased, Decreased fecundity
431 morphological change male reproductive system (UBERON:0000079) 809: malformed, Male reproductive tract
430 decreased hydroxymethylglutaryl-CoA reductase activity (GO:0042282) 3-hydroxy-3-methylglutaryl-coenzyme A reductase (PR:000008636) 804: Inhibition, HMG-CoA reductase
429 decreased cholesterol (CHEBI:16113) None
428 decreased mevalonate (CHEBI:25350) 805: Decreased, mevalonate
427 abnormal signaling (GO:0023052) hypoxia-inducible factor 1-alpha (PR:000008555) 801: modulation, Unknown
426 increased gene expression (GO:0010467) hypoxia-inducible factor 1-alpha (PR:000008555)
425 decreased catalytic activity (GO:0003824) Prolyl hydroxylases (MESH:D064828) 798: Inhibition, Prolyl hydroxylases
424 increased gene expression (GO:0010467) hypoxia-inducible factor 1 (Caenorhabditis elegans) (PR:G5EGD2) 799: Increased, HIF-1 heterodimer
423 decreased aromatase activity (GO:0070330) aromatase isoform 1 (PR:000038849) 800: Decreased, Aromatase (Cyp19a1) mRNA
422 increased hyperplasia (MESH:D006965) urothelial cell (CL:0000731) 796: Increase, Hyperplasia (urothelial)
421 increased cell proliferation (GO:0008283) urothelial cell (CL:0000731) 795: Increase, Regenerative cell proliferation (urothelial cells)
420 increased cell death (GO:0008219) urothelial cell (CL:0000731) 794: Increase, Cytotoxicity (urothelial cells)
419 increased cystolithiasis (MP:0011625) Calculi (MESH:D002137) 793: Increase, Urinary bladder calculi
418 decreased catalytic activity (GO:0003824) 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (rat) (PR:P31214) None
417 increased increased thyroid-stimulating hormone level (MP:0005135) Thyroid stimulating hormone (CHEBI:81567) 753: Increase, Thyroid-stimulating hormone (TSH)
416 decreased catalytic activity (GO:0003824) iodotyrosine deiodinase 1 (mouse) (PR:Q9DCX8) 788: Decrease, Incorporation of active iodide into iodotyrosines
415 increased cell proliferation (GO:0008283) hepatocyte (CL:0000182) 787: Increase, Regenerative cell proliferation (hepatocytes)
414 increased cell death (GO:0008219) hepatocyte (CL:0000182) 786: Increase, Cytotoxicity (hepatocytes)
413 increased hepatocellular carcinoma (MESH:D006528) Adenoma (MESH:D000236) 719: Increase, hepatocellular adenomas and carcinomas
412 increased kidney epithelium hyperplasia (MP:0004968) nephron tubule epithelial cell (CL:1000494) 784: Increase, Hyperplasia (tubular epithelial cells)
411 increased cell death (GO:0008219) nephron tubule epithelial cell (CL:1000494) 783: Increase, Cytotoxicity (tubular epithelial cells)
410 increased Carcinoma, Renal Cell (MESH:D002292) Adenoma (MESH:D000236) 713: Increase, Adenomas/carcinomas (renal tubular)