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All Key Events

Showing 476 to 500 of 1939 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1959	Induction of hERG trafficking defects Short Name Induction of hERG trafficking defects	0	Cellular	Dec 13, 2021	Dec 13, 2021	None
1958	Direct hERG channel blockage Short Name Direct hERG channel blockage	0	Cellular	Dec 13, 2021	Dec 13, 2021	None
1957	hERG channel biogenesis interference Short Name hERG channel biogenesis interference	0	Molecular	Dec 13, 2021	Dec 13, 2021	None
1956	Binding to hERG channel Short Name Binding to hERG channel	0	Molecular	Dec 13, 2021	Dec 13, 2021	None
1955	Acute Myeloid Leukemia Short Name AML	0	Individual	Dec 3, 2021	Dec 3, 2021	432: Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia
1954	Gut microbiota, alteration Short Name Gut dysbiosis	0	Organ	Nov 30, 2021	Jan 4, 2022	428: Binding of S-protein to ACE2 in enterocytes induces ACE2 dysregulation leading to gut dysbiosis
1953	Gestational diabetes mellitus Short Name GDM	0	Individual	Nov 18, 2021	Nov 18, 2021	431: Increased tumor necrosis factor (TNF) leading to increased risk of gestational diabetes mellitus (GDM)
1952	Abnormal, Glucose homeostasis Short Name Abnormal, Glucose homeostasis	0	Organ	Nov 18, 2021	Nov 18, 2021	431: Increased tumor necrosis factor (TNF) leading to increased risk of gestational diabetes mellitus (GDM)
1951	Decrease, Glucose uptake Short Name Decrease, Glucose uptake	0	Cellular	Nov 18, 2021	Nov 18, 2021	431: Increased tumor necrosis factor (TNF) leading to increased risk of gestational diabetes mellitus (GDM)
1950	Increase, TNF Short Name Increase, TNF	0	Molecular	Nov 18, 2021	Nov 18, 2021	431: Increased tumor necrosis factor (TNF) leading to increased risk of gestational diabetes mellitus (GDM)
1949	Decrease, GLUT4 Short Name Decrease, GLUT4	0	Cellular	Nov 18, 2021	Nov 18, 2021	431: Increased tumor necrosis factor (TNF) leading to increased risk of gestational diabetes mellitus (GDM)
1948	Increased ACE2 expression Short Name Upregulation of ACE2	0	Molecular	Oct 28, 2021	Oct 28, 2021	426: SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction.
1947	Pericyte dysfunction Short Name Pericyte dysfunction	0	Cellular	Oct 28, 2021	Oct 28, 2021	426: SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction.
1946	Impaired mechanotransduction of pericytes Short Name	0	Cellular	Oct 28, 2021	Oct 28, 2021	426: SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction.
1945	Dysfunctional Autophagy Short Name Dysfunctional autophagy	0	Cellular	Oct 26, 2021	Oct 26, 2021	2 AOPs 429: A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants 452: Adverse outcome pathway of PM-induced respiratory toxicity
1944	Synaptic dysfunction Short Name Dysfunctional synapses	2	Organ	Oct 26, 2021	Aug 4, 2025	3 AOPs 429: A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants 475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons 471: Neuron defect induced early behavioral change
1943	Hyperphosphorylation of Tau Short Name p-Tau	0	Cellular	Oct 26, 2021	Oct 26, 2021	429: A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants
1942	Accumulation, Cytosolic toxic Tau oligomers Short Name Accumulation, Toxic Tau oligomers	0	Cellular	Oct 26, 2021	Oct 26, 2021	429: A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants
1941	Memory Loss Short Name Memory Loss	0	Individual	Oct 26, 2021	Oct 26, 2021	429: A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants
1939	Viral infection and host-to-host transmission, proliferated Short Name Viral infection, proliferated	1	Individual	Oct 24, 2021	Jun 29, 2024	430: Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation
1938	ACE2 increased shedding Short Name ACE2 increased shedding	0	Molecular	Oct 17, 2021	Oct 17, 2021	427: ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure.
1937	ADAM17 expression induction Short Name ADAM17 induction	0	Cellular	Oct 17, 2021	Oct 17, 2021	427: ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure.
1936	Angiotensin II degradation reduced Short Name Degradation of Ang-II reduced	0	Molecular	Oct 17, 2021	Oct 17, 2021	427: ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure.
1935	Angiotensin (1-7) levels diminished Short Name Ang (1-7) levels reduced	0	Molecular	Oct 15, 2021	Oct 15, 2021	427: ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure.
1934	Myocardial Infarction Short Name Heart attack	0	Organ	Oct 15, 2021	Oct 15, 2021	426: SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction.