AOP-Wiki

API

All Key Events

Showing 1301 to 1325 of 1939 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1079	Increased, Adenomas/carcinomas (mammary) Short Name	2	Tissue	Nov 29, 2016	Sep 16, 2017	2 AOPs 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. 170: Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat
1078	Hyperplasia, Mammary gland Short Name Hyperplasia, Mammary gland	1	Tissue	Nov 29, 2016	Sep 16, 2017	168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat.
1077	Increased, prolactin exposure Short Name Increased, prolactin exposure	1	Tissue	Nov 29, 2016	Dec 3, 2016	168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat.
1076	Increased, circulating estrogen levels Short Name Increased, circulating estrogen levels	1	Organ	Nov 29, 2016	Dec 3, 2016	4 AOPs 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. 169: GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat. 440: Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia 561: Aromatase induction leading to estrogen receptor alpha activation via increased estradiol
1075	prolonged, estrus cycle Short Name prolonged, estrus cycle	2	Individual	Nov 29, 2016	Oct 3, 2025	4 AOPs 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. 169: GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat. 609: Activation, estrogen receptor alpha leads to prolonged estrus cycle via decreased kisspeptin release 640: Activation, estrogen receptor alpha leads to decreased fertility via prolonged estrus cycle
1074	interruption, Ovulation Short Name interruption, Ovulation	1	Individual	Nov 29, 2016	Dec 3, 2016	2 AOPs 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. 169: GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.
1073	anovulation, Short Name anovulation,	0		Nov 29, 2016	Nov 29, 2016	None
1072	Decreased, LH Surge from anterior pituitary Short Name	1	Cellular	Nov 29, 2016	Dec 3, 2016	2 AOPs 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. 169: GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.
1071	Decreased, GnRH pulsatility/release in hypothalamus Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. 169: GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.
1070	Increased, adenosquamous carcinomas of endometrium Short Name	2	Tissue	Nov 29, 2016	Sep 18, 2025	167: Early-life estrogen receptor agonism leading to endometrial adenosquamous carcinoma via promotion of sine oculis homeobox 1 progenitor cells
1069	Increased, Hyperplasia (glandular epithelial cells of endometrium) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	None
1068	Endometrial squamous metaplasia, Increase Short Name	2	Cellular	Nov 29, 2016	Sep 18, 2025	167: Early-life estrogen receptor agonism leading to endometrial adenosquamous carcinoma via promotion of sine oculis homeobox 1 progenitor cells
1067	Proliferation/Clonal Expansion, aberrant basal-type cells Short Name	1	Cellular	Nov 29, 2016	Aug 21, 2025	None
1066	Promotion, Sine oculis homeobox 1 positive progenitor cells in endometrium Short Name	1	Cellular	Nov 29, 2016	Sep 12, 2025	167: Early-life estrogen receptor agonism leading to endometrial adenosquamous carcinoma via promotion of sine oculis homeobox 1 progenitor cells
1065	Activation, estrogen receptor alpha Short Name Activation, ERα	2	Molecular	Nov 29, 2016	Jan 28, 2026	11 AOPs 445: Estrogen Receptor Alpha Agonism leads to Impaired Reproduction 503: Activation of uterine estrogen receptor-alfa leading to endometrial adenocarcinoma, via epigenetic modulation 504: SULT1E1 inhibition leading to uterine adenocarcinoma via increased estrogen availability at target organ level 561: Aromatase induction leading to estrogen receptor alpha activation via increased estradiol 565: 17β-Hydroxysteroid dehydrogenase 2, inhibition leading to activation, estrogen receptor alpha 609: Activation, estrogen receptor alpha leads to prolonged estrus cycle via decreased kisspeptin release 623: Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release 637: Activation, estrogen receptor alpha leads to increased uterine weight via earlier proliferation of cells of the uterine lining 639: Activation, estrogen receptor alpha leads to precocious puberty via increased kisspeptin release 640: Activation, estrogen receptor alpha leads to decreased fertility via prolonged estrus cycle 641: Activation, estrogen receptor alpha leads to increased, phenotypic female-biased sex ratio via increased, differentiation to ovaries
1063	Increased, Pancreatic acinar tumors Short Name Increased, Pancreatic acinar tumors	1	Organ	Nov 29, 2016	Sep 16, 2017	166: PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse
1062	Increased, Cellular proliferation / hyperplasia of acinar cells Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	166: PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse
1061	prolonged, elevation of serun CCK Short Name prolonged, elevation of serun CCK	1	Tissue	Nov 29, 2016	Sep 16, 2017	166: PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse
1060	Alteration, lipid metabolism Short Name Alteration, lipid metabolism	1	Cellular	Nov 29, 2016	Oct 30, 2023	2 AOPs 166: PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse 513: Reactive Oxygen (ROS) formation leads to cancer via Peroxisome proliferation-activated receptor (PPAR) pathway
1059	Increased, cholestasis Short Name Increased, cholestasis	1	Organ	Nov 29, 2016	Sep 16, 2017	166: PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse
1058	Decreased, bile flow Short Name Decreased, bile flow	1	Organ	Nov 29, 2016	Sep 16, 2017	166: PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse
1057	Increased, PPAR-alpha activation Short Name Increased, PPAR-alpha activation	1	Molecular	Nov 29, 2016	Sep 16, 2017	166: PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse
1056	Decrease, E2 blood concentrations at hypothalamus Short Name	1	Tissue	Nov 29, 2016	Sep 16, 2017	2 AOPs 165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse 153: Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats
1054	Promotion, ovarian granular cell tumors Short Name Promotion, ovarian granular cell tumors	1	Cellular	Nov 29, 2016	Dec 3, 2016	165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse
1053	Promotion, ovarian adenomas Short Name Promotion, ovarian adenomas	1	Tissue	Nov 29, 2016	Dec 3, 2016	2 AOPs 165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse 440: Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia