AOP-Wiki

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All Key Events

Showing 1101 to 1125 of 1907 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1559	Facial cartilage structures are reduced in size and morphologically distorted Short Name	0	Tissue	Dec 20, 2018	Dec 20, 2018	2 AOPs 274: Histone deacetylase inhibition leads to impeded craniofacial development 455: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development
1560	Cell differentiation, altered Short Name Cell differentiation, altered	1	Cellular	Dec 20, 2018	Aug 22, 2025	275: Histone deacetylase inhibition leads to neural tube defects
1561	Neural tube defects Short Name Neural tube defects	0	Tissue	Dec 20, 2018	Dec 20, 2018	2 AOPs 275: Histone deacetylase inhibition leads to neural tube defects 449: Ceramide synthase inhibition leading to neural tube defects
1562	Decreased Na/K ATPase activity Short Name Decreased Na/K ATPase activity	1	Cellular	Dec 20, 2018	Dec 3, 2024	5 AOPs 276: Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome 266: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity 516: Na+ /K+ -ATPase inhibition leading to hypertension 539: Decreased Sodium/Potassium ATPase activity leads to Heart failure 556: Decreased Na/K ATPase activity leading to heart failure
1563	Decreased proximal tubular vectorial transport Short Name	0	Tissue	Dec 20, 2018	Dec 20, 2018	276: Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome
1564	Chemical induced Fanconi syndrome Short Name Chemical induced Fanconi syndrome	0	Individual	Dec 20, 2018	Dec 20, 2018	276: Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome
1565	Suppressed AP-1 Short Name Suppressed AP-1	0	Cellular	Dec 24, 2018	Dec 24, 2018	None
1566	Suppressed NF-kB Short Name Suppressed NF-kB	0	Cellular	Dec 24, 2018	Dec 24, 2018	None
1567	Suppressed DC activation Short Name Suppressed DC activation	0	Organ	Dec 24, 2018	Dec 24, 2018	None
1568	Impaired antigen presentation Short Name Impaired antigen presentation	0	Organ	Dec 24, 2018	Dec 24, 2018	None
1569	Impaired T cell activation Short Name Impaired T cell activation	0	Cellular	Dec 24, 2018	Jun 25, 2019	None
1570	Blocking of IL-1R Short Name Blocking of IL-1R	0	Molecular	Dec 24, 2018	Jun 1, 2019	None
1571	Decreased IL-1 production Short Name Decreased IL-1 production	0	Cellular	Dec 24, 2018	Jun 24, 2019	None
1572	Impaired IL-1 signaling Short Name Impaired IL-1 signaling	0	Molecular	Dec 24, 2018	Jun 24, 2019	None
1573	Suppressed MyD88 Short Name Suppressed MyD88	0	Cellular	Jan 6, 2019	Mar 17, 2019	None
1574	Inhibition, IKK complex Short Name Inhibition, IKK complex	0	Molecular	Jan 7, 2019	Jan 7, 2019	278: IKK complex inhibition leading to liver injury
1575	Activation, Caspase 8 pathway Short Name Activation, Caspase 8 pathway	0	Molecular	Jan 7, 2019	Mar 7, 2019	278: IKK complex inhibition leading to liver injury
1576	Activation, Tissue resident cells (Kuppfer cells) Short Name	0	Cellular	Jan 7, 2019	Jan 7, 2019	278: IKK complex inhibition leading to liver injury
1577	Increased, proinflammatory mediators (TNFalpha) Short Name	0	Molecular	Jan 7, 2019	Jan 7, 2019	None
1578	Increase, Necrotic tissue Short Name Increase, Necrotic tissue	0	Tissue	Jan 7, 2019	Jan 7, 2019	None
1579	Increase, proinflammatory mediators (TNFalpha) Short Name	0	Molecular	Jan 7, 2019	Jan 7, 2019	278: IKK complex inhibition leading to liver injury
1580	Binding of microtubule stabilizing agents (MSA) to microtubules Short Name Binding of MSAs to microtubules	0	Molecular	Jan 29, 2019	Jan 29, 2019	279: Microtubule interacting drugs lead to peripheral neuropathy
1581	Disturbance in microtubule dynamic instability Short Name	0	Cellular	Jan 29, 2019	Jan 29, 2019	279: Microtubule interacting drugs lead to peripheral neuropathy
1582	Impaired axonial transport Short Name Impaired axonial transport	0	Cellular	Jan 29, 2019	Jan 29, 2019	3 AOPs 279: Microtubule interacting drugs lead to peripheral neuropathy 429: A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants 471: Neuron defect induced early behavioral change
1583	Sensory axonal peripheral neuropathy Short Name Sensory axonal peripheral neuropathy	0	Individual	Jan 29, 2019	Jan 29, 2019	3 AOPs 279: Microtubule interacting drugs lead to peripheral neuropathy 450: Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality 471: Neuron defect induced early behavioral change