AOP-Wiki

API

All KERs

Showing 2401 to 2425 of 3081 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1056	1016: Inhibition, Feeding	351: Increased Mortality	Nov 29, 2016	Dec 3, 2016	2 AOPs 160: Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality 161: Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality
3087	1016: Inhibition, Feeding	350: Increase, Mortality	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Neuron defect induced early behavioral change
2080	1761: Inhibition, Fin regeneration	1005: Reduced, Swimming performance	Apr 21, 2020	Jul 10, 2020	1 AOP 334: Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration
519	471: Inhibition, FoxA2	472: Down Regulation, CPT1A	Nov 29, 2016	Dec 3, 2016	1 AOP 60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
523	471: Inhibition, FoxA2	474: Down Regulation, HMGCS2	Nov 29, 2016	Dec 3, 2016	1 AOP 60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
804	804: Inhibition, HMG-CoA reductase	805: Decreased, mevalonate	Nov 29, 2016	Dec 3, 2016	1 AOP 124: HMG-CoA reductase inhibition leading to decreased fertility
1827	1574: Inhibition, IKK complex	202: Inhibition, Nuclear factor kappa B (NF-kB)	Jan 7, 2019	Mar 7, 2019	1 AOP 278: IKK complex inhibition leading to liver injury
159	147: Inhibition, Inducible Nitric Oxide Synthase by Metabolite CGA 265307	270: Induction, Sustained Hepatotoxicity	Nov 29, 2016	Dec 3, 2016	1 AOP 32: Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors
1197	1152: Inhibition, Iodotyrosine deiodinase (IYD)	425: Thyroidal Iodide, Decreased	Nov 29, 2016	Dec 3, 2016	1 AOP 188: Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis
2476	1152: Inhibition, Iodotyrosine deiodinase (IYD)	281: T4 in serum, Decreased	Sep 9, 2021	Sep 9, 2021	1 AOP 188: Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis
3587	2348: Inhibition, Liver regeneration	2019: Non-alcoholic fatty liver disease	Aug 16, 2025	Aug 16, 2025	1 AOP 591: DBDPE-induced DNA damage increase in liver leading to Non-alcoholic fatty liver disease via liver steatosis and inhibition of regeneration
1413	1307: Inhibition, LXR	468: Inhibition, PPAR alpha	Apr 12, 2017	Apr 12, 2017	None
1781	1542: Inhibition, Mitochondrial complex III	1545: Decrease in mitochondrial oxidative phosphorylation	Dec 19, 2018	Mar 7, 2019	1 AOP 273: Mitochondrial complex inhibition leading to liver injury
1872	1542: Inhibition, Mitochondrial complex III	1477: OXPHOS, decreased	Mar 19, 2019	Mar 19, 2019	None
2230	1542: Inhibition, Mitochondrial complex III	1771: Decrease, ATP pool	Dec 4, 2020	Dec 4, 2020	1 AOP 286: Mitochondrial complex III antagonism leading to growth inhibition (1)
3637	1542: Inhibition, Mitochondrial complex III	177: Increase, Mitochondrial dysfunction	Sep 24, 2025	Oct 2, 2025	1 AOP 587: Inhibition of the mitochondrial complex III of nigro-striatal neurons leads to parkinsonian motor deficits
2636	105: Inhibition, ETC complexes of the respiratory chain	1770: Decrease, MMP	Apr 8, 2022	Apr 8, 2022	1 AOP 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
2821	105: Inhibition, ETC complexes of the respiratory chain	177: Increase, Mitochondrial dysfunction	Jan 5, 2023	Jan 5, 2023	2 AOPs 480: Mitochondrial complexes inhibition leading to heart failure via decreased ATP production 479: Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress
3241	105: Inhibition, ETC complexes of the respiratory chain	1392: Increase, Oxidative Stress	May 31, 2024	May 31, 2024	1 AOP 437: Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity
475	451: Inhibition, Mitochondrial fatty acid beta-oxidation	327: Accumulation, Fatty acid	Nov 29, 2016	Dec 3, 2016	2 AOPs 57: AhR activation leading to hepatic steatosis 58: NR1I3 (CAR) suppression leading to hepatic steatosis
538	451: Inhibition, Mitochondrial fatty acid beta-oxidation	459: Increase, Liver steatosis	Nov 29, 2016	Dec 3, 2016	1 AOP 61: NFE2L2/FXR activation leading to hepatic steatosis
3638	2258: Inhibition, monocarboxylate transporter 8 (MCT8)	280: T4 in neuronal tissue, Decreased	Sep 29, 2025	Sep 29, 2025	None
3651	2258: Inhibition, monocarboxylate transporter 8 (MCT8)	2093: Decreased brain T4/T3	Oct 8, 2025	Oct 8, 2025	1 AOP 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
1049	1013: Inhibition, Motor neuron activity	1014: Induction, Somatic muscle paralysis	Nov 29, 2016	Dec 3, 2016	None
442	424: Inhibition, Na+/I- symporter (NIS)	425: Thyroidal Iodide, Decreased	Nov 29, 2016	May 29, 2018	3 AOPs 134: Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment 176: Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis

Key Event Relationships (KERs)

All KERs