Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 376 to 400 of 1141 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
766 occurrence regulation of response to reactive oxygen species (GO:1901031) reactive oxygen species (CHEBI:26523) 1634: Increase, Oxidative DNA damage
765 increased response to reactive oxygen species (GO:0000302) reactive oxygen species (CHEBI:26523)
764 increased cellular response to oxidative stress (GO:0034599) reactive oxygen species (CHEBI:26523) 1869: Diminished protective oxidative stress response
763 increased viral translation (GO:0019081) ssRNA viral genome (GO:0019024) 1847: Increased SARS-CoV-2 production
762 increased mRNA transcription (GO:0009299) ssRNA viral genome (GO:0019024) 1847: Increased SARS-CoV-2 production
761 increased viral RNA genome packaging (GO:0019074) viral assembly compartment (GO:0072516) 1847: Increased SARS-CoV-2 production
760 increased viral RNA genome packaging (GO:0019074) None
759 increased Venous thrombosis (HP:0004936) platelet (CL:0000233) 1846: Thrombosis and Disseminated Intravascular Coagulation
758 increased regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043122) 1172: Increased activation, Nuclear factor kappa B (NF-kB)
757 increased positive stranded viral RNA replication (GO:0039690) viral RNA-directed RNA polymerase complex (GO:0031381) 1847: Increased SARS-CoV-2 production
756 increased viral RNA genome replication (GO:0039694) viral RNA-directed RNA polymerase complex (GO:0031381) 1847: Increased SARS-CoV-2 production
755 increased viral RNA genome replication (GO:0039694) None
754 functional change gene expression (GO:0010467) Genome (FMA:84116) 1832: Coordinated gene expression changes by PPARĪ± activation
753 decreased growth (GO:0040007) multicellular organism (UBERON:0000468) 1521: Decrease, Growth
752 decreased cell proliferation (GO:0008283) cell (GO:0005623) 1821: Decrease, Cell proliferation
751 decreased chitin synthase activity (GO:0004100) 1522: Inhibition, Chitin synthase 1
750 decreased ecdysis, chitin-based cuticle (GO:0018990) 1524: Increase, Premature molting
749 decreased cuticle development (GO:0042335) cuticle (UBERON:0001002) 1523: Decrease, Cuticular chitin content
748 decreased protein dephosphorylation (GO:0006470) signal transducer and transcription activator STAT (PR:000001933) 1716: Blockade of STAT5 phosphorylation
747 decreased regulation of binding (GO:0051098) tyrosine-protein kinase JAK3 (PR:000009198) 1715: Inhibition of JAK3
746 decreased T cell activation involved in immune response (GO:0002286) 1719: Impairment of T-cell dependent antibody response
745 decreased negative regulation of DNA binding (GO:0043392) protein-DNA complex (GO:0032993) 1717: Suppression of STAT5 binding to cytokine gene promoters
744 decreased protein dephosphorylation (GO:0006470) None
743 decreased regulation of binding (GO:0051098) None
742 delayed metamorphosis (GO:0007552) 1101: Altered, Amphibian metamorphosis