Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 726 to 750 of 1139 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
726 decreased androgen biosynthetic process (GO:0006702) None
727 decreased androgen biosynthetic process (GO:0006702) 11-Keto-testosterone (CHEBI:34133) 1756: Decreased, plasma 11-ketotestosterone level
728 increased gene expression (GO:0010467) teratocarcinoma-derived growth factor 1 (PR:000030513) None
729 decreased activin receptor signaling pathway (GO:0032924) activin complex (GO:0048180) None
730 decreased activin receptor signaling pathway (GO:0032924) activin receptor complex (GO:0048179) None
731 decreased fin regeneration (GO:0031101) blastemal cell (CL:0000354) 1761: Inhibition, Fin regeneration
732 disrupted androgen receptor signaling pathway (GO:0030521) Musculature of male perineum (FMA:264621) 1688: anogenital distance (AGD), decreased
733 abnormal Abnormal spermatogenesis (HP:0008669) Mature sperm cell (FMA:67338) 1758: Impaired, Spermatogenesis
734 decreased cholesterol transport (GO:0030301) cholesterol (CHEBI:16113) 807: Decreased, cholesterol
735 decreased cholesterol transport (GO:0030301) cholesteryl ester (CHEBI:17002) 807: Decreased, cholesterol
736 occurrence EEG with focal epileptiform discharges (HP:0011185) neuron part (GO:0097458) None
737 occurrence EEG with focal epileptiform discharges (HP:0011185) neuron (CL:0000540) 1623: Occurrence, Focal Seizure
738 occurrence secondary generalized seizure (NBO:0000703) brain (UBERON:0000955) 1788: Status epilepticus
739 decreased population growth rate (PCO:0000008) population of organisms (PCO:0000001) 360: Decrease, Population growth rate
740 increased male gonad development (GO:0008584) immature gonad (UBERON:2005272) 1790: Increased, Differentiation to Testis
741 increased male sex differentiation (GO:0046661) population of organisms (PCO:0000001) 1791: Increased, Male Biased Sex Ratio
742 delayed metamorphosis (GO:0007552) 1101: Altered, Amphibian metamorphosis
743 decreased regulation of binding (GO:0051098) None
744 decreased protein dephosphorylation (GO:0006470) None
745 decreased negative regulation of DNA binding (GO:0043392) protein-DNA complex (GO:0032993) 1717: Suppression of STAT5 binding to cytokine gene promoters
746 decreased T cell activation involved in immune response (GO:0002286) 1719: Impairment of T-cell dependent antibody response
747 decreased regulation of binding (GO:0051098) tyrosine-protein kinase JAK3 (PR:000009198) 1715: Inhibition of JAK3
748 decreased protein dephosphorylation (GO:0006470) signal transducer and transcription activator STAT (PR:000001933) 1716: Blockade of STAT5 phosphorylation
749 decreased cuticle development (GO:0042335) cuticle (UBERON:0001002) 1523: Decrease, Cuticular chitin content
750 decreased ecdysis, chitin-based cuticle (GO:0018990) 1524: Increase, Premature molting