Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 776 to 800 of 1145 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
370 increased binding (GO:0005488) major urinary protein (rat) (PR:P02761) 714: Increased, Binding of chemicals to 2u (serum)
369 increased major urinary protein (rat) (PR:P02761) 708: Increased, Accumulation of alpha2u microglobulin (proximal tubular epithelium)
368 increased hyperplasia (MESH:D006965) kidney tubule cell (CL:1000507) 767: Increase, Hyperplasia (renal tubular cells)
367 increased Carcinoma (MESH:D002277)
366 increased Adenoma (MESH:D000236)
365 increased epithelial cell proliferation (GO:0050673) nephron tubule epithelial cell (CL:1000494) None
364 increased cell death (GO:0008219) kidney tubule cell (CL:1000507) 709: Increase, Cytotoxicity (renal tubular cell)
363 decreased ion channel activity (GO:0005216) ATP-sensitive inward rectifier potassium channel 1 (PR:000001978) 697: impaired, ion channels
362 decreased ion channel activity (GO:0005216) potassium voltage-gated channel subfamily H member 2 (human) (PR:Q12809) 697: impaired, ion channels
361 increased Arrhythmias, Cardiac (MESH:D001145) 699: Increased, cardiac arrthymia
360 abnormal action potential (GO:0001508) 698: Altered, Action Potential
359 increased deactivation of mitotic spindle assembly checkpoint (GO:1902426) MAD2 like protein (fruit fly) (PR:Q9VNE1) 695: Upregulated, Spindle assembly checkpoint protein Mad2-oocyte
358 decreased signaling (GO:0023052) steroid hormone (CHEBI:26764) 692: Reduced, Maturation inducing steroid receptor signalling, oocyte
357 abnormal chromosome segregation (GO:0007059) 696: Increased, Chromosome misseggregation
356 decreased G2/MI transition of meiotic cell cycle (GO:0008315) 694: Reduced, Meiotic prophase I/metaphase I transition, oocyte
355 decreased steroid hormone receptor activity (GO:0003707) steroid hormone (CHEBI:26764) 692: Reduced, Maturation inducing steroid receptor signalling, oocyte
354 decreased steroid hormone (CHEBI:26764) 691: Reduced, Maturation inducing steroid, plasma
353 decreased Gonadotropin Releasing Hormone (MESH:D007987) 689: Reduced, Gonadotropin releasing hormone, hypothalamus
352 increased 3',5'-cyclic AMP(1-) (CHEBI:58165) 693: Increased, cyclic adenosine monophosphate
351 decreased mating pheromone secretion (GO:0071834) pheromone (CHEBI:26013) 678: Reduced, Pheromone release
350 decreased reproduction (GO:0000003)
349 decreased attraction-related behavior (NBO:0000280) 674: Reduced, Ability to attract spawning mates
348 abnormal fertility (MESH:D005298) 673: Reduced, Spawning behavior
347 decreased prostaglandin biosynthetic process (GO:0001516) prostaglandin F2alpha (CHEBI:15553)
346 decreased prostaglandin F2alpha (CHEBI:15553)