Key Event Components

Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
A complete list of all KECs is available in TSV format on the Downloads Page.

Showing 776 to 800 of 1141 KECs

ID	Action	Process	Object	Associated Key Events (KEs)


366	increased		Adenoma (MESH:D000236)	9 Events 713: Increase, Adenomas/carcinomas (renal tubular) 719: Increase, hepatocellular adenomas and carcinomas 736: Increase, Adenomas/carcinomas (bronchioloalveolar) 741: Increase, Adenomas/carcinomas (follicular cell) 773: Increase, Endometrial adenocarcinomas 797: Increase, Adenomas/carcinomas (urothelial) 1026: Increased Apoptosis, Adenomas/carcinomas (follicular cell) 1053: Promotion, ovarian adenomas 1079: Increased, Adenomas/carcinomas (mammary)
365	increased	epithelial cell proliferation (GO:0050673)	nephron tubule epithelial cell (CL:1000494)	None
364	increased	cell death (GO:0008219)	kidney tubule cell (CL:1000507)	709: Increase, Cytotoxicity (renal tubular cell)
363	decreased	ion channel activity (GO:0005216)	ATP-sensitive inward rectifier potassium channel 1 (PR:000001978)	697: impaired, ion channels
362	decreased	ion channel activity (GO:0005216)	potassium voltage-gated channel subfamily H member 2 (human) (PR:Q12809)	697: impaired, ion channels
361	increased	Arrhythmias, Cardiac (MESH:D001145)		699: Increased, cardiac arrthymia
360	abnormal	action potential (GO:0001508)		698: Altered, Action Potential
359	increased	deactivation of mitotic spindle assembly checkpoint (GO:1902426)	MAD2 like protein (fruit fly) (PR:Q9VNE1)	695: Upregulated, Spindle assembly checkpoint protein Mad2-oocyte
358	decreased	signaling (GO:0023052)	steroid hormone (CHEBI:26764)	692: Reduced, Maturation inducing steroid receptor signalling, oocyte
357	abnormal	chromosome segregation (GO:0007059)		696: Increased, Chromosome misseggregation
356	decreased	G2/MI transition of meiotic cell cycle (GO:0008315)		694: Reduced, Meiotic prophase I/metaphase I transition, oocyte
355	decreased	steroid hormone receptor activity (GO:0003707)	steroid hormone (CHEBI:26764)	692: Reduced, Maturation inducing steroid receptor signalling, oocyte
354	decreased		steroid hormone (CHEBI:26764)	691: Reduced, Maturation inducing steroid, plasma
353	decreased		Gonadotropin Releasing Hormone (MESH:D007987)	689: Reduced, Gonadotropin releasing hormone, hypothalamus
352	increased		3',5'-cyclic AMP(1-) (CHEBI:58165)	693: Increased, cyclic adenosine monophosphate
351	decreased	mating pheromone secretion (GO:0071834)	pheromone (CHEBI:26013)	678: Reduced, Pheromone release
350	decreased	reproduction (GO:0000003)		2 Events 675: Reduced, Reproductive Success 1277: Reproductive failure
349	decreased	attraction-related behavior (NBO:0000280)		674: Reduced, Ability to attract spawning mates
348	abnormal		fertility (MESH:D005298)	673: Reduced, Spawning behavior
347	decreased	prostaglandin biosynthetic process (GO:0001516)	prostaglandin F2alpha (CHEBI:15553)	2 Events 672: Reduced, Prostaglandin F2alpha synthesis, ovary 681: Decreased, Prostaglandin F2alpha synthesis, ovary
346	decreased		prostaglandin F2alpha (CHEBI:15553)	2 Events 671: Reduced, Prostaglandin F2alpha concentration, plasma 1104: Decreased, Prostaglandin F2alpha concentration, plasma
345	increased		anesthesia (MESH:D000758)	634: N/A, sedation
344	decreased	locomotion (GO:0040011)		635: Decreased, locomotion
343	decreased	rhythmic excitation (GO:0043179)	histaminergic neuron (CL:0011110)	633: Decrease, histaminergic neuron excitation
342	decreased	histamine receptor activity (GO:0004969)	histamine H2 receptor (PR:000001423)	638: Antagonism, Histamine Receptor (H2)