Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 401 to 425 of 1139 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
401 increased cell death (GO:0008219) corneal epithelial cell (CL:0000575) 776: Increase, Cytotoxicity (corneal cells)
402 increased inflammatory response (GO:0006954) corneal epithelial cell (CL:0000575) 777: Increase, Inflammation (corneal cells)
403 increased cell proliferation (GO:0008283) corneal epithelial cell (CL:0000575) 778: Increase, Regenerative cell proliferation (corneal cells)
404 increased papilloma (MESH:D010212) 779: Increase, Papillomas/carcinomas (squamous cells)
405 increased tyrosine (CHEBI:18186) 775: Increased, Plasma tyrosine
406 decreased 4-hydroxyphenylpyruvate dioxygenase activity (GO:0003868) 4-hydroxyphenylpyruvate dioxygenase (rat) (PR:P32755) 766: Inhibition, 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) enzyme
407 increased cell death (GO:0008219) epithelial cell (CL:0000066) 780: Increase, Cytotoxicity (epithelial cells)
408 increased cell proliferation (GO:0008283) epithelial cell (CL:0000066)
409 increased stomach epithelial hyperplasia (MP:0005493) epithelial cell (CL:0000066) 782: Increase, Hyperplasia (forestomach epithelial cells)
410 increased Carcinoma, Renal Cell (MESH:D002292) Adenoma (MESH:D000236) 713: Increase, Adenomas/carcinomas (renal tubular)
411 increased cell death (GO:0008219) nephron tubule epithelial cell (CL:1000494) 783: Increase, Cytotoxicity (tubular epithelial cells)
412 increased kidney epithelium hyperplasia (MP:0004968) nephron tubule epithelial cell (CL:1000494) 784: Increase, Hyperplasia (tubular epithelial cells)
413 increased hepatocellular carcinoma (MESH:D006528) Adenoma (MESH:D000236) 719: Increase, hepatocellular adenomas and carcinomas
414 increased cell death (GO:0008219) hepatocyte (CL:0000182) 786: Increase, Cytotoxicity (hepatocytes)
415 increased cell proliferation (GO:0008283) hepatocyte (CL:0000182) 787: Increase, Regenerative cell proliferation (hepatocytes)
416 decreased catalytic activity (GO:0003824) iodotyrosine deiodinase 1 (mouse) (PR:Q9DCX8) 788: Decrease, Incorporation of active iodide into iodotyrosines
417 increased increased thyroid-stimulating hormone level (MP:0005135) Thyroid stimulating hormone (CHEBI:81567) 753: Increase, Thyroid-stimulating hormone (TSH)
418 decreased catalytic activity (GO:0003824) 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (rat) (PR:P31214) None
419 increased cystolithiasis (MP:0011625) Calculi (MESH:D002137) 793: Increase, Urinary bladder calculi
420 increased cell death (GO:0008219) urothelial cell (CL:0000731) 794: Increase, Cytotoxicity (urothelial cells)
421 increased cell proliferation (GO:0008283) urothelial cell (CL:0000731) 795: Increase, Regenerative cell proliferation (urothelial cells)
422 increased hyperplasia (MESH:D006965) urothelial cell (CL:0000731) 796: Increase, Hyperplasia (urothelial)
423 decreased aromatase activity (GO:0070330) aromatase isoform 1 (PR:000038849) 800: Decreased, Aromatase (Cyp19a1) mRNA
424 increased gene expression (GO:0010467) hypoxia-inducible factor 1 (Caenorhabditis elegans) (PR:G5EGD2) 799: Increased, HIF-1 heterodimer
425 decreased catalytic activity (GO:0003824) Prolyl hydroxylases (MESH:D064828) 798: Inhibition, Prolyl hydroxylases