Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 676 to 700 of 1139 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
676 decreased glutathione synthase activity (GO:0004363) glutathione synthetase (PR:000008293) 1286: Down Regulation, GSS and GSTs gene
677 decreased glutathione transferase activity (GO:0004364) glutathione S-transferase (PR:000029945) 1286: Down Regulation, GSS and GSTs gene
678 decreased glutathione biosynthetic process (GO:0006750) glutathione (CHEBI:16856) 1287: Glutathione synthesis
679 abnormal cholesterol (CHEBI:16113) 1289: Perturbation of cholesterol
680 abnormal glutathione (CHEBI:16856) 1290: Glutathione homeostasis
681 increased signaling (GO:0023052) JNK Mitogen-Activated Protein Kinases (MESH:D048031) 1292: Activation, JNK
682 increased signaling (GO:0023052) forkhead box protein O (Caenorhabditis elegans) (PR:O16850) 1293: Activation, FOXO
683 abnormal signaling (GO:0023052) Wnt signalosome (GO:1990909) 1294: Inhibition, Wnt pathway
684 abnormal embryo development (GO:0009790) 1295: Defect of Embryogenesis
685 decreased NMDA glutamate receptor activity (GO:0004972) NMDA selective glutamate receptor complex (GO:0017146) 195: Inhibition, NMDARs
686 increased NMDA glutamate receptor activity (GO:0004972) NMDA selective glutamate receptor complex (GO:0017146) 388: Overactivation, NMDARs
687 decreased glutamate secretion (GO:0014047) glutamate(1-) (CHEBI:14321) 383: Reduced, Presynaptic release of glutamate
688 increased neuropeptide hormone activity (GO:0005184) Calcitonin gene-related peptide 1 (CHEBI:80337) 1433: Increased CGRP, neuronal release of CGRP
689 increased neuropeptide hormone activity (GO:0005184) Neurokinin A (CHEBI:80311) 1435: Increased neurokinin A (NKA) by neuronal cells
690 increased epithelial cell proliferation (GO:0050673) kidney tubule cell (CL:1000507) 710: Increase, Regenerative cell proliferation (tubular epithelial cells)
691 increased acute inflammatory response (GO:0002526) Cytokine (FMA:84050) None
692 increased cell activation involved in immune response (GO:0002263) leukocyte (CL:0000738) 1494: Leukocyte recruitment/activation
693 increased cell activation involved in immune response (GO:0002263) tissue-resident macrophage (CL:0000864) None
694 increased cell activation involved in immune response (GO:0002263) 1492: Tissue resident cell activation
695 increased acute inflammatory response (GO:0002526) 1493: Increased Pro-inflammatory mediators
696 decreased vascular endothelial growth factor A (PR:000017284) None
697 decreased abnormal protein level (MP:0008469) vascular endothelial growth factor A (PR:000017284) 948: reduced production, VEGF
698 decreased enzyme inhibitor activity (GO:0004857) histone deacetylase 1 (PR:000008478) 1502: Histone deacetylase inhibition
699 increased regulation of protein modification process (GO:0031399) histone (CHEBI:15358) 1503: Histone acetylation, increase
700 increased positive regulation of gene expression (GO:0010628) cyclin-dependent kinase inhibitor (PR:000000014) 1504: p21 (CDKN1A) expression, increase