Key Event Components

Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
A complete list of all KECs is available in TSV format on the Downloads Page.

Showing 176 to 200 of 1139 KECs

ID	Action	Process	Object	Associated Key Events (KEs)


176	increased		triglyceride (CHEBI:17855)	291: Accumulation, Triglyceride
177	functional change	mitochondrion disassembly (GO:0061726)	mitochondrion (GO:0005739)	None
178	occurrence		fatty liver (MESH:D005234)	345: N/A, Liver Steatosis
179	increased		membrane (GO:0016020)	46: Accumulation, Biological membranes
180	abnormal		plasma membrane (GO:0005886)	169: Disruption, Membrane integrity
181	decreased	peroxisome proliferator activated receptor signaling pathway (GO:0035357)	peroxisome proliferator-activated receptor alpha (PR:000013056)	3 Events 231: Decreased, PPAR-alpha activation 468: Inhibition, PPAR alpha 1057: Increased, PPAR-alpha activation
182	decreased	peroxisome proliferator activated receptor signaling pathway (GO:0035357)	peroxisome proliferator-activated receptor delta (PR:000013057)	232: Decreased, PPAR-beta activation
183	decreased	peroxisome proliferator activated receptor signaling pathway (GO:0035357)	peroxisome proliferator-activated receptor gamma (PR:000013058)	2 Events 233: Decreased, PPAR-gamma activation 1028: Activation of specific nuclear receptors, PPAR-gamma activation
184	increased		fatty acid (CHEBI:35366)	327: Accumulation, Fatty acid
185	decreased	gene expression (GO:0010467)	3-hydroxyacyl-CoA dehydrogenase type-2 (PR:000008774)	140: Decreased, HSD17B10 expression
186	decreased	3-hydroxyacyl-CoA dehydrogenase activity (GO:0003857)	3-hydroxyacyl-CoA dehydrogenase type-2 (PR:000008774)	2 Events 8: Decreased, 3-hydroxyacyl-CoA dehydrogenase type-2 activity 1288: Activation, 3-hydroxy-3-methylglutaryl-CoA reductase gene
187	increased		fatty liver (MESH:D005234)	None
188	increased	collagen biosynthetic process (GO:0032964)	collagen (CHEBI:3815)	68: Increase, Collagen accumulation
189	increased	hepatic stellate cell activation (GO:0035733)	hepatic stellate cell (CL:0000632)	265: Increase, Hepatic stellate cell activation
190	increased	protein alkylation (GO:0008213)		244: Alkylation, Protein
191	increased	macrophage activation (GO:0042116)	Kupffer cell (CL:0000091)	134: Increase, Kupffer cell activation
192	occurrence	liver fibrosis (MP:0003333)	liver (UBERON:0002107)	2 Events 344: Increase, Liver fibrosis 840: Formation, Liver fibrosis
193	increased	transforming growth factor beta1 production (GO:0032905)	TGF-beta 1 (PR:000000182)	276: Up Regulation, TGFbeta1 expression
194	increased	covalent binding (MI:0195)	xenobiotic (CHEBI:35703)	75: N/A, Covalent binding to protein, possibly lysine residue
195	increased	chemokine activity (GO:0008009)	Chemokine (FMA:241981)	151: Activation, Inflammatory cytokines, chemokines, cytoprotective gene pathways
196	increased	cytokine activity (GO:0005125)	Cytokine (FMA:84050)	151: Activation, Inflammatory cytokines, chemokines, cytoprotective gene pathways
197	increased	Respiratory Hypersensitivity (MESH:D012130)		313: Increase, Allergic Respiratory Hypersensitivity Response
198	increased	protein binding (GO:0005515)	electrophilic reagant (CHEBI:59739)	396: Covalent Binding, Protein
199	increased	keratinocyte activation (GO:0032980)		826: Activation, Keratinocytes
200	increased	cytokine production involved in inflammatory response (GO:0002534)		826: Activation, Keratinocytes