API

Aop: 119

AOP Title

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Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse)

Short name:

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Thyroid peroxidase- follicular adenoma/carcinoma

Authors

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Cancer AOP Workgroup. National Health and Environmental Effects Research Laboratory, Office of Research and Development, Integrated Systems Toxicology Division, US Environmental Protection Agency, Research Triangle Park, NC. Corresponding author for wiki entry (wood.charles@epa.gov)

Point of Contact

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Charles Wood

Contributors

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  • Charles Wood

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development 1.29 Included in OECD Work Plan


This AOP was last modified on December 03, 2016 16:37

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Revision dates for related pages

Page Revision Date/Time
Thyroperoxidase, Inhibition September 16, 2017 10:15
Decrease, Incorporation of active iodide into iodotyrosines September 16, 2017 10:16
Increase, Hypertrophy and proliferation (follicular cell) September 16, 2017 10:16
Increase, Hyperplasia (follicular cells) September 16, 2017 10:16
Increase, Thyroid-stimulating hormone (TSH) September 16, 2017 10:16
Increase, Adenomas/carcinomas (follicular cell) September 16, 2017 10:16
Decrease, Serum thyroid hormone (T4/T3) September 16, 2017 10:16
Thyroperoxidase, Inhibition leads to Decrease, Incorporation of active iodide into iodotyrosines December 03, 2016 16:38
Decrease, Incorporation of active iodide into iodotyrosines leads to Decrease, Serum thyroid hormone (T4/T3) December 03, 2016 16:38
Decrease, Serum thyroid hormone (T4/T3) leads to Increase, Thyroid-stimulating hormone (TSH) December 03, 2016 16:38
Increase, Thyroid-stimulating hormone (TSH) leads to Increase, Hypertrophy and proliferation (follicular cell) December 03, 2016 16:38
Increase, Hypertrophy and proliferation (follicular cell) leads to Increase, Hyperplasia (follicular cells) December 03, 2016 16:38
Increase, Hyperplasia (follicular cells) leads to Increase, Adenomas/carcinomas (follicular cell) December 03, 2016 16:38

Abstract

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This putative adverse outcome pathway (AOP) outlines potential key events leading to a tumor outcome in standard carcinogenicity models. This information is based largely on modes of action described previously in cited literature sources and is intended as a resource template for AOP development and data organization. Presentation in this Wiki does not indicate EPA acceptance of a particular pathway for a given reference agent, only that the information has been proposed in some manner. In addition, this putative AOP relates to the model species indicated and does not directly address issues of human relevance.


Background (optional)

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Summary of the AOP

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Stressors

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Molecular Initiating Event

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Title Short name
Thyroperoxidase, Inhibition Thyroperoxidase, Inhibition

Key Events

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Title Short name
Decrease, Incorporation of active iodide into iodotyrosines Decrease, Incorporation of active iodide into iodotyrosines
Increase, Hypertrophy and proliferation (follicular cell) Increase, Hypertrophy and proliferation (follicular cell)
Increase, Hyperplasia (follicular cells) Increase, Hyperplasia (follicular cells)
Increase, Thyroid-stimulating hormone (TSH) Increase, Thyroid-stimulating hormone (TSH)
Decrease, Serum thyroid hormone (T4/T3) Decrease, Serum thyroid hormone (T4/T3)

Adverse Outcome

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Title Short name
Increase, Adenomas/carcinomas (follicular cell) Increase, Adenomas/carcinomas (follicular cell)

Relationships Between Two Key Events (Including MIEs and AOs)

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Network View

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Life Stage Applicability

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Taxonomic Applicability

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Term Scientific Term Evidence Link
Rattus norvegicus Rattus norvegicus NCBI
Mus musculus Mus musculus NCBI

Sex Applicability

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Sex Evidence
Male
Female

Graphical Representation

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Click to download graphical representation template

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Weight of Evidence Summary

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Quantitative Considerations

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Considerations for Potential Applications of the AOP (optional)

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References

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Dellarco, V. L., McGregor, D., Berry, S. C., Cohen, S. M., & Boobis, A. R. (2006). Thiazopyr and thyroid disruption: case study within the context of the 2006 IPCS Human Relevance Framework for analysis of a cancer mode of action. Crit Rev Toxicol, 36(10), 793-801. doi: 10.1080/10408440600975242

Hurley, P. M. (1998). Mode of carcinogenic action of pesticides inducing thyroid follicular cell tumors in rodents. Environ Health Perspect, 106(8), 437-445.

U.S. Environmental Protection Agency, R. A. F. (Mar. 1998). Assessment of Thyroid Follicular Cell Tumors. Washington, DC.