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AOP: 466
Title
Doda decarboxylase leading to mortality
Short name
Graphical Representation
Point of Contact
Contributors
- Donggon Yoo
- Woo-Keun Kim
Coaches
OECD Information Table
OECD Project # | OECD Status | Reviewer's Reports | Journal-format Article | OECD iLibrary Published Version |
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This AOP was last modified on October 07, 2024 19:04
Revision dates for related pages
Page | Revision Date/Time |
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Decrease, Tyrosine | August 28, 2022 20:50 |
Decrease, dopa decarboxylase | August 28, 2022 20:51 |
Increase, Defects in tanning of new cuticle | August 28, 2022 20:52 |
Increase, impairment of cuticle sclerotization | August 28, 2022 20:53 |
Increase, pigmentation | August 28, 2022 20:56 |
Increase, Incomplete ecdysis | May 24, 2018 16:41 |
Increase, delay in oviposition | August 28, 2022 20:58 |
Increase, Mortality | October 26, 2020 05:18 |
Decrease, hatching of egg | August 28, 2022 20:59 |
Decrease, Tyrosine leads to Decrease, dopa decarboxylase | August 28, 2022 21:00 |
Decrease, dopa decarboxylase leads to Increase, Defects in tanning of new cuticle | August 28, 2022 21:00 |
Increase, Defects in tanning of new cuticle leads to Increase, impairment of cuticle sclerotization | August 28, 2022 21:00 |
Increase, Defects in tanning of new cuticle leads to Increase, pigmentation | August 28, 2022 21:01 |
Increase, impairment of cuticle sclerotization leads to Increase, Incomplete ecdysis | August 28, 2022 21:02 |
Increase, pigmentation leads to Increase, Incomplete ecdysis | August 28, 2022 21:02 |
Increase, Incomplete ecdysis leads to Increase, delay in oviposition | August 28, 2022 21:03 |
Increase, Incomplete ecdysis leads to Increase, Mortality | December 03, 2016 16:38 |
Increase, Incomplete ecdysis leads to Decrease, hatching of egg | August 28, 2022 21:03 |
Abstract
We propose this AOP associated with the molting process based on the literatures. Cuticle tanning occurs in insects immediately after hatching or molting. During this process, the cuticle becomes pigmented and sclerotized due to melanin deposition and protein crosslinking. In insects, different from mammals, melanin is synthesized mainly from dopamine, which is produced from 3,4-dihydroxyphenylalanine (DOPA) by the enzyme DOPA decarboxylase (Ddc). Silencing of Ddc has been shown to cause incomplete and premature molting or failed pupation. This process affects pigmentation and cuticle sclerosis, resulting in an incomplete moulting process. The incomplete moulting process increases the mortality rate of immature individuals and causes problems in the reproductive process.
AOP Development Strategy
Context
Strategy
We proposed the conceptual AOP framework associated with Dopa decarboxylase leading to mortality based on the literature review. The molecular mechanism of dopa decarboxylase’s molting is relatively clear based on the paper. However, the supporting information on Dopa decarboxylase and related KEs is not sufficient yet. We believe our animal model experimental data and further gene analysis can validate the key regulators in the suggested AOP. Then, we can suggest essentiality and evidence for each KEs based on animal model studies. The process for this AOP validation needs at least one year. This AOP is related to the molting process. It is thought that it will be helpful for research use together with the existing AOP (4, 358~361).
Summary of the AOP
Events:
Molecular Initiating Events (MIE)
Key Events (KE)
Adverse Outcomes (AO)
Type | Event ID | Title | Short name |
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MIE | 2051 | Decrease, Tyrosine | Decrease, Tyrosine |
KE | 2052 | Decrease, dopa decarboxylase | Decrease, dopa decarboxylase |
KE | 2053 | Increase, Defects in tanning of new cuticle | Increase, Defects in tanning of new cuticle |
KE | 2054 | Increase, impairment of cuticle sclerotization | Increase, impairment of cuticle sclerotization |
KE | 2055 | Increase, pigmentation | Increase, pigmentation |
KE | 990 | Increase, Incomplete ecdysis | Increase, Incomplete ecdysis |
KE | 2056 | Increase, delay in oviposition | Increase, delay in oviposition |
KE | 350 | Increase, Mortality | Increase, Mortality |
KE | 2057 | Decrease, hatching of egg | Decrease, hatching of egg |
Relationships Between Two Key Events (Including MIEs and AOs)
Title | Adjacency | Evidence | Quantitative Understanding |
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Decrease, Tyrosine leads to Decrease, dopa decarboxylase | adjacent | Moderate | Moderate |
Decrease, dopa decarboxylase leads to Increase, Defects in tanning of new cuticle | adjacent | Moderate | Moderate |
Increase, Defects in tanning of new cuticle leads to Increase, impairment of cuticle sclerotization | adjacent | Moderate | Moderate |
Increase, Defects in tanning of new cuticle leads to Increase, pigmentation | adjacent | Moderate | Moderate |
Increase, impairment of cuticle sclerotization leads to Increase, Incomplete ecdysis | adjacent | Moderate | Moderate |
Increase, pigmentation leads to Increase, Incomplete ecdysis | adjacent | Moderate | Moderate |
Increase, Incomplete ecdysis leads to Increase, delay in oviposition | adjacent | Moderate | Moderate |
Increase, Incomplete ecdysis leads to Increase, Mortality | adjacent | Moderate | Moderate |
Increase, Incomplete ecdysis leads to Decrease, hatching of egg | adjacent | Moderate | Moderate |
Network View
Prototypical Stressors
Life Stage Applicability
Taxonomic Applicability
Sex Applicability
Overall Assessment of the AOP
Domain of Applicability
Essentiality of the Key Events
Evidence Assessment
Known Modulating Factors
Modulating Factor (MF) | Influence or Outcome | KER(s) involved |
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