AOP-Wiki

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All Key Events

Showing 376 to 400 of 1939 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

2064	Increase, Cytosolic calcium Short Name Increase, Cytosolic Ca	0	Cellular	Sep 13, 2022	Sep 13, 2022	265: Uncoupling of oxidative phosphorylation leading to growth inhibition via increased cytosolic calcium
2063	Decrease, New cuticle secretion Short Name Decrease, New cuticle secretion	0	Organ	Aug 28, 2022	Aug 28, 2022	467: Knickkopf leading to mortality
2062	Weak, Procuticle protection Short Name Weak, Procuticle protection	0	Organ	Aug 28, 2022	Aug 28, 2022	467: Knickkopf leading to mortality
2061	Decrease, Prevent chitin degradation by chitinases Short Name	0	Tissue	Aug 28, 2022	Aug 28, 2022	467: Knickkopf leading to mortality
2060	Decrease, Chitin laminar organization Short Name Decrease, Chitin laminar organization	0	Tissue	Aug 28, 2022	Aug 28, 2022	467: Knickkopf leading to mortality
2059	Decrease, knickkopf gene Short Name Decrease, knickkopf gene	0	Cellular	Aug 28, 2022	Aug 28, 2022	467: Knickkopf leading to mortality
2058	Decrease, 20-hydroxyecdysone Short Name Decrease, 20-hydroxyecdysone	0	Molecular	Aug 28, 2022	Aug 28, 2022	467: Knickkopf leading to mortality
2057	Decrease, hatching of egg Short Name Decrease, hatching of egg	0	Individual	Aug 28, 2022	Aug 28, 2022	466: Doda decarboxylase leading to mortality
2056	Increase, delay in oviposition Short Name Increase, delay in oviposition	0	Individual	Aug 28, 2022	Aug 28, 2022	466: Doda decarboxylase leading to mortality
2055	Increase, pigmentation Short Name Increase, pigmentation	0	Individual	Aug 28, 2022	Aug 28, 2022	466: Doda decarboxylase leading to mortality
2054	Increase, impairment of cuticle sclerotization Short Name	0	Individual	Aug 28, 2022	Aug 28, 2022	466: Doda decarboxylase leading to mortality
2053	Increase, Defects in tanning of new cuticle Short Name	0	Individual	Aug 28, 2022	Aug 28, 2022	466: Doda decarboxylase leading to mortality
2052	Decrease, dopa decarboxylase Short Name Decrease, dopa decarboxylase	0	Cellular	Aug 28, 2022	Aug 28, 2022	466: Doda decarboxylase leading to mortality
2051	Decrease, Tyrosine Short Name Decrease, Tyrosine	0	Molecular	Aug 28, 2022	Aug 28, 2022	466: Doda decarboxylase leading to mortality
2050	Increase, developmental abnormalities Short Name Increase, developmental abnormalities	0	Individual	Aug 28, 2022	Aug 28, 2022	2 AOPs 465: Alcohol dehydrogenase leading to reproductive dysfunction 467: Knickkopf leading to mortality
2049	Increase, sex ratio (F/M) Short Name Increase, sex ratio (F/M)	0	Individual	Aug 28, 2022	Aug 28, 2022	465: Alcohol dehydrogenase leading to reproductive dysfunction
2048	Increase, Body volume of female adults Short Name Increase, Body volume of female adults	0	Individual	Aug 28, 2022	Aug 28, 2022	465: Alcohol dehydrogenase leading to reproductive dysfunction
2047	Delay, Ovarian maturation Short Name Delay, Ovarian maturation	0	Cellular	Aug 28, 2022	Aug 28, 2022	465: Alcohol dehydrogenase leading to reproductive dysfunction
2046	Increase, Vitellogenin mRNA Short Name Increase, Vitellogenin mRNA	0	Molecular	Aug 28, 2022	Aug 28, 2022	465: Alcohol dehydrogenase leading to reproductive dysfunction
2045	Increase, Alcohol dehydrogenase Short Name Increase, Alcohol dehydrogenase	0	Molecular	Aug 28, 2022	Aug 28, 2022	465: Alcohol dehydrogenase leading to reproductive dysfunction
2044	Decrease, Smoothend relocation and activation Short Name Decrease, SMO relocation	1	Cellular	Aug 23, 2022	Oct 27, 2022	460: Antagonism of Smoothened receptor leading to orofacial clefting
2043	Decrease, Sonic Hedgehog second messenger production Short Name	1	Cellular	Aug 12, 2022	Mar 22, 2023	3 AOPs 460: Antagonism of Smoothened receptor leading to orofacial clefting 491: Decrease, GLI1/2 target gene expression leads to orofacial clefting 502: Decrease, cholesterol synthesis leads to orofacial clefting
2042	Increase, Orofacial clefting Short Name orofacial cleft	2	Individual	Jul 27, 2022	Apr 3, 2025	3 AOPs 460: Antagonism of Smoothened receptor leading to orofacial clefting 491: Decrease, GLI1/2 target gene expression leads to orofacial clefting 502: Decrease, cholesterol synthesis leads to orofacial clefting
2041	Decrease, facial prominence outgrowth Short Name Decrease, facial prominence outgrowth	2	Tissue	Jul 27, 2022	Apr 3, 2025	3 AOPs 460: Antagonism of Smoothened receptor leading to orofacial clefting 491: Decrease, GLI1/2 target gene expression leads to orofacial clefting 502: Decrease, cholesterol synthesis leads to orofacial clefting
2040	Decrease, GLI1/2 target gene expression Short Name Decrease, GLI1/2 target gene expression	2	Cellular	Jul 25, 2022	Apr 2, 2025	3 AOPs 460: Antagonism of Smoothened receptor leading to orofacial clefting 491: Decrease, GLI1/2 target gene expression leads to orofacial clefting 502: Decrease, cholesterol synthesis leads to orofacial clefting