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All Key Events

Showing 176 to 200 of 1939 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

2266	Demyelination, increased Short Name Demyelination, increased	2	Cellular	Oct 1, 2024	Oct 1, 2024	3 AOPs 543: Inhibition of neuropathy target esterase leading to delayed neuropathy via lysolecithin cell membrane integration 544: Inhibition of neuropathy target esterase leading to delayed neuropathy via increased inflammation 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
2265	Oligodendrocyte death, increased Short Name Oligodendrocyte death, increased	1	Cellular	Oct 1, 2024	Oct 1, 2024	2 AOPs 543: Inhibition of neuropathy target esterase leading to delayed neuropathy via lysolecithin cell membrane integration 544: Inhibition of neuropathy target esterase leading to delayed neuropathy via increased inflammation
2264	Lysolecithin cell membrane integration, increased Short Name	0	Cellular	Oct 1, 2024	Oct 1, 2024	543: Inhibition of neuropathy target esterase leading to delayed neuropathy via lysolecithin cell membrane integration
2263	Lysolecithin, increased Short Name LPS, increased	1	Cellular	Oct 1, 2024	Oct 1, 2024	2 AOPs 543: Inhibition of neuropathy target esterase leading to delayed neuropathy via lysolecithin cell membrane integration 544: Inhibition of neuropathy target esterase leading to delayed neuropathy via increased inflammation
2262	Neuropathy target esterase, inhibited Short Name NTE, inhibited	1	Molecular	Oct 1, 2024	Oct 1, 2024	2 AOPs 543: Inhibition of neuropathy target esterase leading to delayed neuropathy via lysolecithin cell membrane integration 544: Inhibition of neuropathy target esterase leading to delayed neuropathy via increased inflammation
2261	Decreased, blood plasma volume Short Name Decreased, blood plasma volume	1	Tissue	Sep 20, 2024	Dec 3, 2024	539: Decreased Sodium/Potassium ATPase activity leads to Heart failure
2260	Gluten-reactive CD4+ T cells, activation Short Name	1	Cellular	Sep 13, 2024	Jan 4, 2025	524: Gluten-driven immune activation leading to celiac disease in genetically predisposed individuals
2259	Altered, Microbial Bile Acid Metabolism Short Name Microbial Bile Acid Dysmetabolism	0	Molecular	Aug 29, 2024	Aug 29, 2024	None
2258	Inhibition, monocarboxylate transporter 8 (MCT8) Short Name	1	Molecular	Aug 28, 2024	Nov 24, 2025	610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
2257	Celiac disease Short Name Celiac disease	1	Individual	Aug 13, 2024	Dec 2, 2024	524: Gluten-driven immune activation leading to celiac disease in genetically predisposed individuals
2256	Gluten-reactive B cells and transglutaminase 2-reactive B cells, activation Short Name	1	Cellular	Aug 13, 2024	Jan 4, 2025	524: Gluten-driven immune activation leading to celiac disease in genetically predisposed individuals
2255	Innate immune response, activation Short Name	1	Cellular	Aug 13, 2024	Apr 3, 2025	524: Gluten-driven immune activation leading to celiac disease in genetically predisposed individuals
2254	Gluten-reactive and transglutaminase 2 reactive B cell receptors, generation Short Name	1	Molecular	Aug 13, 2024	Dec 3, 2024	524: Gluten-driven immune activation leading to celiac disease in genetically predisposed individuals
2253	Gluten-reactive T cell receptors, generation Short Name	1	Molecular	Aug 13, 2024	Jan 5, 2025	524: Gluten-driven immune activation leading to celiac disease in genetically predisposed individuals
2252	Human leukocyte antigen DQ2/8-gluten complexes, formation Short Name Formation of HLA-DQ2/8-gluten complexes	1	Molecular	Aug 13, 2024	Jan 5, 2025	524: Gluten-driven immune activation leading to celiac disease in genetically predisposed individuals
2251	Estradiol availability, increased Short Name Increased E2 availability	2	Tissue	Aug 9, 2024	Nov 21, 2024	4 AOPs 504: SULT1E1 inhibition leading to uterine adenocarcinoma via increased estrogen availability at target organ level 561: Aromatase induction leading to estrogen receptor alpha activation via increased estradiol 565: 17β-Hydroxysteroid dehydrogenase 2, inhibition leading to activation, estrogen receptor alpha 566: Decreased, GnRH pulsatility/release leading to estradiol availability, increased via impaired ovulation
2250	17β-Hydroxysteroid dehydrogenase 2, inhibition Short Name HSD17B2 inhibition	0	Molecular	Aug 9, 2024	Aug 12, 2024	565: 17β-Hydroxysteroid dehydrogenase 2, inhibition leading to activation, estrogen receptor alpha
2249	Activation of sensory receptors Short Name Activation of sensory receptors	0	Molecular	Jul 29, 2024	Jul 29, 2024	None
2248	Increased stress hormone Short Name Increased stress hormone	0	Cellular	Jul 29, 2024	Jul 29, 2024	None
2247	Increased incidence of cerebrovascular morbidility and mortality in the general population Short Name	0	Population	Jul 29, 2024	Jul 29, 2024	None
2246	Increased sympathetic nerve activity Short Name Increased sympathetic nerve activity	0	Cellular	Jul 29, 2024	Jul 29, 2024	None
2245	Altered Cell Differentiation Signaling Short Name Altered cell differentiation signaling	2	Molecular	Jul 24, 2024	Apr 18, 2025	2 AOPs 482: Deposition of energy leading to occurrence of bone loss 334: Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration
2244	Altered Stress Response Signaling Short Name Altered Stress Response Signaling	1	Molecular	Jul 24, 2024	Nov 15, 2024	2 AOPs 470: Deposition of energy leads to abnormal vascular remodeling 483: Deposition of Energy Leading to Learning and Memory Impairment
2243	Succinate Accumulation Short Name Succinate Accumulation	0	Cellular	Jul 18, 2024	Jul 18, 2024	2 AOPs 474: Succinate dehydrogenase inactivation leads to cancer by promoting EMT 546: Succinate dehydrogenase inactivation leads to cancer through hypoxic-like mechanisms
2242	Abnormality, dendritic spine morphology Short Name Dendritic spine abnormality	4	Cellular	Jul 14, 2024	Mar 12, 2025	475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons