Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 226 to 250 of 1139 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
226 increased mutation (MESH:D009154) cellular tumor antigen p53 (PR:000003035) 376: Increased, Induced Mutations in Critical Genes
227 increased hepatocyte proliferation (GO:0072574) hepatocyte (CL:0000182)
228 functional change DNA repair (GO:0006281) Nuclear deoxyribonucleic acid (FMA:67194) 493: Increased, Insufficient repair or mis-repair of pro-mutagenic DNA adducts
229 increased ionotropic glutamate receptor activity (GO:0004970) ionotropic glutamate receptor complex (GO:0008328) 875: Binding of agonist, Ionotropic glutamate receptors
230 increased hormone biosynthetic process (GO:0042446) Luteinizing hormone (CHEBI:81568) 414: Increase, Luteinizing hormone (LH)
231 abnormal sex ratio (MESH:D012744) 417: skewed, sex ratio
232 functional change glomerular basement membrane (UBERON:0005777) 421: Increased, glomerular rupture and renal hemorrhaging
233 increased hemorrhage (MP:0001914)
234 increased Nephropathy (HP:0000112) 422: Increased, nephropathy
235 decreased sodium:iodide symporter activity (GO:0008507) sodium/iodide cotransporter (PR:000015171) 424: Inhibition, Na+/I- symporter (NIS)
236 decreased iodide transport (GO:0015705) iodide (CHEBI:16382)
237 abnormal abnormal neuron morphology (MP:0002882) 851: Decrease of GABAergic interneurons
238 decreased secretion (GO:0046903) very-low-density lipoprotein (CHEBI:39027) 450: Decrease, Very low-density lipoprotein export capacity
239 decreased gene expression (GO:0010467) phosphoenolpyruvate carboxykinase, cytosolic [GTP] (PR:000012416) 216: Decreased, PCK1 expression (control point for glycolysis/gluconeogenesis pathway)
240 increased fatty acid transport (GO:0015908) fatty acid (CHEBI:35366) 465: Increased, Fatty acid influx
241 increased gene expression (GO:0010467) low-density lipoprotein receptor (PR:000009744) 466: Up Regulation, LDLR (low density lipoprotein receptor)
242 increased receptor-mediated endocytosis (GO:0006898) low-density lipoprotein (CHEBI:39026) 467: Increased, LDL uptake
243 increased gene expression (GO:0010467) cytochrome P450 1A1 (PR:000006101) 80: Up Regulation, CYP1A1
244 decreased signaling (GO:0023052) nuclear receptor subfamily 1 group I member 3 (PR:000011398) 456: Suppression, Constitutive androstane receptor, NR1l3
245 increased signaling (GO:0023052) sterol regulatory element-binding protein 1 (PR:000015611) 457: Activation, SREBF1
246 increased triglyceride biosynthetic process (GO:0019432) triglyceride (CHEBI:17855) 454: Increased, Triglyceride formation
247 increased gene expression (GO:0010467) fatty acid synthase (PR:000007348) 463: Up Regulation, FAS
248 increased acetyl-CoA carboxylase activity (GO:0003989) acetyl-CoA carboxylase 1 (PR:000003596) 470: Up Regulation, Acetyl-CoA carboxylase-1 (ACC-1)
249 decreased signaling (GO:0023052) hepatocyte nuclear factor 4-alpha (PR:000008654) 461: Suppression, HNF4alpha
250 decreased signaling (GO:0023052) hepatocyte nuclear factor 3-beta (PR:000007603) 471: Inhibition, FoxA2