Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 401 to 425 of 1145 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
745 decreased negative regulation of DNA binding (GO:0043392) protein-DNA complex (GO:0032993) 1717: Suppression of STAT5 binding to cytokine gene promoters
744 decreased protein dephosphorylation (GO:0006470) None
743 decreased regulation of binding (GO:0051098) None
742 delayed metamorphosis (GO:0007552) 1101: Altered, Amphibian metamorphosis
741 increased male sex differentiation (GO:0046661) population of organisms (PCO:0000001) 1791: Increased, Male Biased Sex Ratio
740 increased male gonad development (GO:0008584) immature gonad (UBERON:2005272) 1790: Increased, Differentiation to Testis
739 decreased population growth rate (PCO:0000008) population of organisms (PCO:0000001) 360: Decrease, Population growth rate
738 occurrence secondary generalized seizure (NBO:0000703) brain (UBERON:0000955) 1788: Status epilepticus
737 occurrence EEG with focal epileptiform discharges (HP:0011185) neuron (CL:0000540) 1623: Occurrence, Focal Seizure
736 occurrence EEG with focal epileptiform discharges (HP:0011185) neuron part (GO:0097458) None
735 decreased cholesterol transport (GO:0030301) cholesteryl ester (CHEBI:17002) 807: Decreased, cholesterol
734 decreased cholesterol transport (GO:0030301) cholesterol (CHEBI:16113) 807: Decreased, cholesterol
733 abnormal Abnormal spermatogenesis (HP:0008669) Mature sperm cell (FMA:67338) 1758: Impaired, Spermatogenesis
732 disrupted androgen receptor signaling pathway (GO:0030521) Musculature of male perineum (FMA:264621) 1688: anogenital distance (AGD), decreased
731 decreased fin regeneration (GO:0031101) blastemal cell (CL:0000354) 1761: Inhibition, Fin regeneration
730 decreased activin receptor signaling pathway (GO:0032924) activin receptor complex (GO:0048179) None
729 decreased activin receptor signaling pathway (GO:0032924) activin complex (GO:0048180) None
728 increased gene expression (GO:0010467) teratocarcinoma-derived growth factor 1 (PR:000030513) None
727 decreased androgen biosynthetic process (GO:0006702) 11-Keto-testosterone (CHEBI:34133) 1756: Decreased, plasma 11-ketotestosterone level
726 decreased androgen biosynthetic process (GO:0006702) None
725 increased Wnt protein secretion (GO:0061355) protein-serine O-palmitoleoyltransferase porcupine (PR:000030936) 1754: Increase, porcupine-induced Wnt secretion and Wnt signaling activation
724 increased G-protein coupled acetylcholine receptor binding (GO:0031789) muscarinic acetylcholine receptor (PR:000001488) 1602: Increased Muscarinic Acetylcholine Receptors
723 increased Testicular atrophy (HP:0000029) Testis (FMA:7210) 1506: Testicular atrophy
722 disrupted tubulin complex (GO:0045298) 718: Binding, Tubulin
721 increased DNA molecule region (FMA:84119) None