Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 751 to 775 of 1139 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
751 decreased chitin synthase activity (GO:0004100) 1522: Inhibition, Chitin synthase 1
752 decreased cell proliferation (GO:0008283) cell (GO:0005623) 1821: Decrease, Cell proliferation
753 decreased growth (GO:0040007) multicellular organism (UBERON:0000468) 1521: Decrease, Growth
754 functional change gene expression (GO:0010467) Genome (FMA:84116) 1832: Coordinated gene expression changes by PPARĪ± activation
755 increased viral RNA genome replication (GO:0039694) None
756 increased viral RNA genome replication (GO:0039694) viral RNA-directed RNA polymerase complex (GO:0031381) 1847: Increased SARS-CoV-2 production
757 increased positive stranded viral RNA replication (GO:0039690) viral RNA-directed RNA polymerase complex (GO:0031381) 1847: Increased SARS-CoV-2 production
758 increased regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043122) 1172: Increased activation, Nuclear factor kappa B (NF-kB)
759 increased Venous thrombosis (HP:0004936) platelet (CL:0000233) 1846: Thrombosis and Disseminated Intravascular Coagulation
760 increased viral RNA genome packaging (GO:0019074) None
761 increased viral RNA genome packaging (GO:0019074) viral assembly compartment (GO:0072516) 1847: Increased SARS-CoV-2 production
762 increased mRNA transcription (GO:0009299) ssRNA viral genome (GO:0019024) 1847: Increased SARS-CoV-2 production
763 increased viral translation (GO:0019081) ssRNA viral genome (GO:0019024) 1847: Increased SARS-CoV-2 production
764 increased cellular response to oxidative stress (GO:0034599) reactive oxygen species (CHEBI:26523) 1869: Diminished protective oxidative stress response
765 increased response to reactive oxygen species (GO:0000302) reactive oxygen species (CHEBI:26523)
766 occurrence regulation of response to reactive oxygen species (GO:1901031) reactive oxygen species (CHEBI:26523) 1634: Increase, Oxidative DNA damage
767 increased endocytosis involved in viral entry into host cell (GO:0075509) None
768 increased protease binding (GO:0002020) None
769 increased neuropilin binding (GO:0038191) None
770 disrupted mRNA transcription (GO:0009299) angiotensin-converting enzyme 2 (PR:000003622) None
771 occurrence regulation of beta-catenin-TCF complex assembly (GO:1904863) beta-catenin-TCF complex (GO:1990907) 1755: beta-catenin activation
772 occurrence epithelial to mesenchymal transition (GO:0001837) cellular_component (GO:0005575) None
773 occurrence regulation of cellular response to drug (GO:2001038) 1651: Treatment-resistant gastric cancer
774 increased deoxyribonucleic acid (CHEBI:16991) 1879: Bulky DNA adducts, increase
775 decreased protein secretion (GO:0009306) None