Key Event Components

Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
A complete list of all KECs is available in TSV format on the Downloads Page.

Showing 826 to 850 of 1141 KECs

ID	Action	Process	Object	Associated Key Events (KEs)


316	increased	increased susceptibility to viral infection (MP:0002418)		576: Increased, Viral susceptibility
315	decreased	abnormal maternal nurturing (MP:0001386)		565: Reduced, Brood care
314	increased	Appetite (MESH:D001066)		574: Increased, Appetite and hunger
313	increased	Stress, Physiological (MESH:D013312)		2 Events 573: Increase, Energetic demands and therefore metabolic stress 1110: Increased, Energetic demands and therefore metabolic stress
312	increased	increased energy expenditure (MP:0004889)		2 Events 573: Increase, Energetic demands and therefore metabolic stress 1110: Increased, Energetic demands and therefore metabolic stress
311	decreased		population of organisms (PCO:0000001)	572: Decrease, Number of worker bees
310	abnormal	DNA repair (GO:0006281)	Mitochondrial deoxyribonucleic acid (FMA:67199)	664: Overwhelmed, Mitochondrial DNA repair mechanisms
309	premature	aging (GO:0007568)		571: Accelerated, Aging
308	functional change	response to wounding (GO:0009611)	Mitochondrial deoxyribonucleic acid (FMA:67199)	570: Accumulation, Damaged mitochondrial DNA
307	abnormal	thermoregulation behavior (NBO:0000051)		568: impaired, Hive thermoregulation
306	decreased	reproductive behavior (GO:0019098)		565: Reduced, Brood care
305	abnormal	signaling (GO:0023052)	calmodulin (PR:000004978)	1243: Altered, Ca2+-calmodulin activated signal transduction
304	abnormal	binding (GO:0005488)	calcium ion (CHEBI:39124)	1243: Altered, Ca2+-calmodulin activated signal transduction
303	increased	colony collapse (MESH:D056631)		2 Events 563: Death/Failure, Colony 1107: Weakened, Colony
302	abnormal	foraging behavior (GO:0060756)		560: Abnormal, Foraging activity and behavior
301	increased	acetylcholine receptor activity (GO:0015464)	Nicotinic acetylcholine receptor (FMA:61796)	559: Activation, Nicotinic acetylcholine receptor
300	increased	DNA hypermethylation (GO:0044026)		662: Decreased testosterone by the fetal Leydig cells, Hypermethylation in the fetal testis
299	increased	abnormal chromosome number (MP:0004023)		3 Events 536: Altered, Chromosome number (polyploid) zygote 723: Altered, Chromosome number 728: Increase, Aneuploid offspring
298	abnormal	sperm entry (GO:0035037)		535: Abnormal, Sperm penetration (polyspermy)
297	abnormal		fertilization envelope (GO:0060387)	534: Altered, Formation of cortical envelope
296	decreased	secretion (GO:0046903)	cortical granule (GO:0060473)	533: Decreased, Cortical granule release/distribution upon fertilization
295	delayed	abnormal ovulation (MP:0001928)		532: Delayed, Ovulation
294	decreased	regulation of luteinizing hormone secretion (GO:0033684)	Luteinizing hormone (CHEBI:81568)	531: Decreased, LH Surge
293	decreased	hormone secretion (GO:0046879)	Gonadotropin Releasing Hormone (MESH:D007987)	3 Events 530: Decreased, GnRH pulsatility/release 969: Decreased GnRH Release, Decreased Kisspeptin stimulation of GnRH neurons 1071: Decreased, GnRH pulsatility/release in hypothalamus
292	decreased	signaling (GO:0023052)	proto-oncogene c-Fos (mouse) (PR:P01101)	529: Decreased, GnRH cfos activity