Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 51 to 75 of 1141 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
1091 increased cell death (GO:0008219) cell (GO:0005623) 1825: Increase, Cell death
1090 decreased response to odorant (GO:1990834) Nose (FMA:46472) 2317: Loss of olfactory function
1089 increased Pulmonary edema (HP:0100598) lung (UBERON:0002048) 2316: Increased, pulmonary edema
1088 decreased decreased neurotransmitter release (MP:0003990) CNS neuron (sensu Vertebrata) (CL:0000117) 1944: Synaptic dysfunction
1087 decreased Premature ovarian failure (HP:0008209) ovarian follicle (UBERON:0001305) 2305: Premature ovarian Insufficiency
1086 decreased cytochrome-c oxidase activity (GO:0004129) mitochondrion (GO:0005739) 1840: Inhibition, cytochrome oxidase
1085 increased wounding (MP:0013027) Nose (FMA:46472) 2312: Increased, nasal lesions
1084 increased apoptosis regulator BAX (PR:000002193) 2124: increased, Bax expression
1083 increased aromatase activity (GO:0070330) aromatase (PR:000006100) 2293: Aromatase, induction
1082 increased estradiol secretion (GO:0035938) Glandular part of endometrium (FMA:86488) 2251: Estradiol availability, increased
1081 increased serotonin receptor signaling pathway (GO:0007210) 5-hydroxytryptamine receptor 2C (PR:000001168) 2308: Increased, stimulation of brain serotonin 5-HT1a, 5-HT2c receptors
1080 increased serotonin receptor signaling pathway (GO:0007210) 5-hydroxytryptamine receptor 1A (PR:000001161) 2308: Increased, stimulation of brain serotonin 5-HT1a, 5-HT2c receptors
1079 abnormal embryonic organ development (GO:0048568) penis (UBERON:0000989) 2082: Hypospadias, increased
1078 increased serotonin receptor signaling pathway (GO:0007210) Serotonin receptor (FMA:67372) None
1077 increased increased serotonin level (MP:0010069) serotonin (CHEBI:28790) 1320: Increased, extracellular serotonin
1076 increased increased serotonin level (MP:0010069) extracellular region (GO:0005576) 1320: Increased, extracellular serotonin
1075 increased serotonin receptor activity (GO:0099589) Surface of brain (FMA:86594) 2308: Increased, stimulation of brain serotonin 5-HT1a, 5-HT2c receptors
1074 occurrence cornification (GO:0070268) epithelium of vagina (UBERON:0001344) 2306: Persistent vaginal cornification
1073 increased aryl hydrocarbon receptor binding (GO:0017162) aryl hydrocarbon receptor (PR:000003858) 18: Activation, AhR
1072 abnormal behavior (GO:0007610) 2301: Abnormal, Behavior
1071 disrupted abnormal lipid metabolism (MP:0013245) 2300: Disruption, Glucolipid metabolism
1070 disrupted glucose metabolic process (GO:0006006) 2300: Disruption, Glucolipid metabolism
1069 abnormal cell redox homeostasis (GO:0045454) 2299: Altered, Redox Homeostasis
1068 occurrence cell activation involved in immune response (GO:0002263) None
1067 increased hormone activity (GO:0005179) tissue (UBERON:0000479) None