Key Event Components

Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
A complete list of all KECs is available in TSV format on the Downloads Page.

Showing 1126 to 1141 of 1141 KECs

ID	Action	Process	Object	Associated Key Events (KEs)


16	increased	mortality (MESH:D009026)		4 Events 351: Increased Mortality 350: Increase, Mortality 1135: Reduced fitness or even mortality, Acidosis, hypovolemic shock and organ dysfunction 947: Increase, Early Life Stage Mortality
15	increased	muscle contraction (GO:0006936)		2 Events 993: Decrease, Abdominal muscle contraction 601: Overactivation, muscle contraction
14	increased	chitin biosynthetic process (GO:0006031)	chitin (CHEBI:17029)	990: Increase, Incomplete ecdysis
13	decreased	ecdysis-triggering hormone activity (GO:0008255)		988: Decrease, Circulating ecdysis triggering hormone
12	increased	ecdysone receptor-mediated signaling pathway (GO:0035076)	ecdysone receptor holocomplex (GO:0008230)	103: Increase, Ecdysone receptor hyperactivation
11	occurrence		Parkinsonian disorders (MESH:D020734)	896: Parkinsonian motor deficits
10	increased	loss of dopaminergic neurons (MP:0003244)		890: Degeneration of dopaminergic neurons of the nigrostriatal pathway
9	pathological	brain inflammation (MP:0001847)	astrocyte (CL:0000127)	188: Neuroinflammation
8	pathological	brain inflammation (MP:0001847)	microglial cell (CL:0000129)	188: Neuroinflammation
7	abnormal	Proteostasis deficiencies (MESH:D057165)	protein (CHEBI:36080)	889: Proteostasis, impaired
6	functional change		mitochondrion (GO:0005739)	2 Events 177: Increase, Mitochondrial dysfunction 2363: Elevated mitochondrial ROS and dysfunction
5	decreased	NADH dehydrogenase (ubiquinone) activity (GO:0008137)	NADH-ubiquinone oxidoreductase chain 1 (PR:000031316)	887: Inhibition, NADH-ubiquinone oxidoreductase (complex I)
4	decreased	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	NADH-ubiquinone oxidoreductase chain 1 (PR:000031316)	888: Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)
3	increased	hepatocellular carcinoma (MESH:D006528)		334: Promotion, Hepatocelluar carcinoma
2	increased	hyperplasia (MESH:D006965)		3 Events 142: Hyperplasia, Hyperplasia 415: Hyperplasia, Leydig cell 1192: Increased, Ductal Hyperplasia
1	increased	cell proliferation (GO:0008283)		3 Events 57: Proliferation, Cell proliferation in the absence of cytotoxicity 416: Increase proliferation, Leydig cell 1182: Increase, Cell Proliferation (Epithelial Cells)