Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 76 to 100 of 1141 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
1066 increased hormone activity (GO:0005179) None
1065 decreased ovulation (GO:0030728) Ovum (FMA:67343) 1695: Impaired ovulation
1064 decreased fertilization (GO:0009566) fertility (MESH:D005298) 406: decreased, Fertility
1063 disrupted ovulation cycle (GO:0042698) ovarian follicle (UBERON:0001305) 405: disrupted, ovarian cycle
1062 disrupted meiosis I (GO:0007127) oocyte (CL:0000023) 1882: Disrupted, initiation of meiosis of oogonia in the ovary
1061 decreased ovarian follicle development (GO:0001541) ovarian follicle (UBERON:0001305) 1883: Decreased, size of the ovarian reserve
1060 decreased retinoic acid biosynthetic process (GO:0002138) all-trans-retinoic acid (CHEBI:15367) 1881: Decreased, all-trans retinoic acid (atRA) concentration
1059 decreased retinoic acid biosynthetic process (GO:0002138) retinal dehydrogenase 1 (PR:000003920) 1880: Decreased, ALDH1A (RALDH) enzyme activity
1058 occurrence B cell activation involved in immune response (GO:0002312) B cell (CL:0000236) 2256: Gluten-reactive B cells and transglutaminase 2-reactive B cells, activation
1057 occurrence T cell activation involved in immune response (GO:0002286) T cell (CL:0000084) 2260: Gluten-reactive CD4+ T cells, activation
1056 occurrence immune system process (GO:0002376) 2255: Innate immune response, activation
1055 occurrence dendritic cell migration (GO:0036336) professional antigen presenting cell (CL:0000145) 2275: Gluten reactive adaptive T-cells with antigen presenting cells, co-localization
1054 occurrence T cell migration (GO:0072678) T cell (CL:0000084) 2275: Gluten reactive adaptive T-cells with antigen presenting cells, co-localization
1053 occurrence gene conversion of immunoglobulin genes (GO:0002206) B cell receptor complex (GO:0019815) 2254: Gluten-reactive and transglutaminase 2 reactive B cell receptors, generation
1052 occurrence gene conversion (GO:0035822) alpha-beta T cell receptor complex (GO:0042105) 2253: Gluten-reactive T cell receptors, generation
1051 occurrence antigen presentation trait (VT:0001835) Human leukocyte antigen complex (FMA:84795) 2252: Human leukocyte antigen DQ2/8-gluten complexes, formation
1050 pathological Celiac disease (HP:0002608) intestinal epithelial cell (CL:0002563) 2257: Celiac disease
1049 increased increased circulating total protein level (MP:0005568) proprotein convertase subtilisin/kexin type 9 (PR:000012440) 2276: Increased, protein expression of proprotein convertase subtilisin/kexin type 9 (PCSK9)
1048 increased increased circulating LDL cholesterol level (MP:0000182) low-density lipoprotein cholesterol (CHEBI:47774) 2271: Increased, plasma low-density lipoprotein (LDL) cholesterol
1047 decreased decreased circulating total protein level (MP:0005567) insulin-induced gene 1 protein (PR:000009056) 2268: Decreased, insulin-induced gene 1 (INSIG1) protein activity
1046 increased increased circulating total protein level (MP:0005568) sterol regulatory element-binding protein 2 (PR:000015612) 2269: Increased, Sterol Regulatory Element Binding Protein 2 (SREBP2) protein expression
1045 decreased insulin-induced gene 1 protein (PR:000009056) None
1044 increased immune system process (GO:0002376) None
1043 increased dendritic cell migration (GO:0036336) professional antigen presenting cell (CL:0000145) None
1042 increased T cell migration (GO:0072678) T cell (CL:0000084) None