Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 26 to 50 of 1139 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
26 decreased fatty acid beta-oxidation (GO:0006635) fatty acid (CHEBI:35366)
27 decreased ketosis (MESH:D007662)
28 abnormal abnormal lipid homeostasis (MP:0002118) 862: Not Increased, Circulating Ketone Bodies
29 abnormal ketone body (CHEBI:73693) 862: Not Increased, Circulating Ketone Bodies
30 increased protein catabolic process (GO:0030163) muscle protein (MESH:D009124) 863: Increased, Catabolism of Muscle Protein
31 decreased weight loss (MP:0001263) None
32 decreased aromatase activity (GO:0070330) aromatase (PR:000006100)
33 decreased 17beta-estradiol (CHEBI:16469)
34 decreased estrogen biosynthetic process (GO:0006703) 17beta-estradiol (CHEBI:16469)
35 decreased fertility (MESH:D005298) 406: decreased, Fertility
36 disrupted ovulation cycle (GO:0042698) None
37 increased signaling (GO:0023052) nuclear receptor subfamily 1 group I member 2 (PR:000011397)
38 increased signaling (GO:0023052) nuclear receptor subfamily 1 group I member 3 (PR:000011398) 715: Activation, Constitutive androstane receptor
39 increased glucuronosyltransferase activity (GO:0015020) beta-1,3-glucuronyltransferase (PR:000001325) 295: Induction, Upregulation of glucuronyltransferase activity
40 increased excretion (GO:0007588) Tetrahydroaldosterone-3-glucuronide (CHEBI:88728) 401: Increase, Biliary excretion TH glucuronide
41 decreased thyroxine (CHEBI:30660)
42 abnormal regulation of gene expression (GO:0010468) hippocampal formation (UBERON:0002421) 756: Hippocampal gene expression, Altered
43 morphological change hippocampal formation (UBERON:0002421) None
44 abnormal chemical synaptic transmission (GO:0007268) None
45 increased cochlear degeneration (MP:0000032) 319: Loss, Cochlear function
46 increased GABA receptor binding (GO:0050811) gamma-aminobutyric acid receptor subunit alpha-1 (PR:000007766) 667: Binding at picrotoxin site, iGABAR chloride channel
47 increased GABA receptor binding (GO:0050811) gamma-aminobutyric acid receptor subunit alpha-5 (PR:000007770) 667: Binding at picrotoxin site, iGABAR chloride channel
48 increased GABA receptor binding (GO:0050811) gamma-aminobutyric acid receptor subunit alpha-6 (PR:000007771) 667: Binding at picrotoxin site, iGABAR chloride channel
49 decreased GABA-gated chloride ion channel activity (GO:0022851) chloride (CHEBI:17996)
50 occurrence membrane depolarization (GO:0051899) 616: Occurrence, A paroxysmal depolarizing shift