Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 976 to 1000 of 1139 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
976 disrupted regulation of gene expression (GO:0010468) 2224: Dysregulation of transcriptional expression within PPAR signaling network
977 disrupted lipid storage (GO:0019915) 2225: Disrupted Lipid Storage
978 decreased interleukin-1 receptor activity (GO:0004908) interleukin-1 receptor type I (PR:000001363) 1700: Impaired IL-1R1 signaling in T cell
979 abnormal animal organ development (GO:0048513) gonad (UBERON:0000991) 1615: Impaired inguinoscrotal testicular descent phase
980 pathological negative regulation of synaptic plasticity (GO:0031914) postsynaptic actin cytoskeleton (GO:0098871) 2242: Abnormality, dendritic spine morphology
981 morphological change abnormal excitatory postsynaptic current amplitude (MP:0011267) dendritic spine membrane (GO:0032591) 388: Overactivation, NMDARs
982 decreased impaired synaptic plasticity (MP:0001900) actin cytoskeleton of dendritic spine (GO:0098938) None
983 decreased postsynaptic actin cytoskeleton organization (GO:0098974) drebrin (PR:000006296) 2078: Loss of drebrin
984 disrupted synapse (GO:0045202) 2005: Altered neurotransmission in development
985 disrupted voltage-gated sodium channel activity (GO:0005248) 1353: Binding to voltage-gated sodium channel
986 functional change sodium channel activity (GO:0005272) voltage-gated sodium channel complex (GO:0001518) 1977: Disruption of sodium channel gating kinetics
987 decreased sodium:potassium-exchanging ATPase activity (GO:0005391) None
988 decreased import into cell (GO:0098657) sodium atom (CHEBI:26708) None
989 increased blood viscosity trait (VT:3000004) blood (UBERON:0000178) 2238: Increased, Blood viscosity
990 occurrence Stress, Physiological (MESH:D013312) heart (UBERON:0000948) None
991 occurrence Cardiac arrest (HP:0001695) heart (UBERON:0000948) 1535: Heart failure
992 increased estradiol (CHEBI:23965) 2251: Estradiol availability, increased
993 increased energy deposition event (RBO:00015021) 1686: Deposition of Energy
994 increased DNA Strand Break (NCI:C25830) Deoxyribonucleic acid (FMA:74412) 1635: Increase, DNA strand breaks
995 decreased neurogenesis (GO:0022008) 2098: Increase, Abnormal Neural Remodeling
996 increased demyelination (MP:0000921)
997 increased neuron death (GO:0070997) 2098: Increase, Abnormal Neural Remodeling
998 increased cell surface receptor signaling pathway (GO:0007166)
999 abnormal cell differentiation (GO:0030154) 2245: Altered Cell Differentiation Signaling
1000 abnormal DNA repair (GO:0006281) deoxyribonucleic acid (CHEBI:16991) 155: Inadequate DNA repair