Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 201 to 225 of 1139 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
201 increased cell activation (GO:0001775)
202 increased MHC protein complex assembly (GO:0002396) 398: Activation, Dendritic Cells
203 increased T cell activation (GO:0042110) T cell (CL:0000084) 272: Activation/Proliferation, T-cells
204 increased cell proliferation (GO:0008283) memory T cell (CL:0000813) 272: Activation/Proliferation, T-cells
205 increased signaling (GO:0023052) aryl hydrocarbon receptor (PR:000003858) 165: Activation, Long term AHR receptor driven direct and indirect gene expression changes
206 abnormal cellular homeostasis (GO:0019725) 853: Changes/Inhibition, Cellular Homeostasis and Apoptosis
207 decreased apoptotic process (GO:0006915)
208 occurrence Liver Diseases (MESH:D008107) 139: N/A, Hepatotoxicity, Hepatopathy, including a constellation of observable effects
209 abnormal cell proliferation (GO:0008283) Liver cell (FMA:63179) 854: Alterations, Cellular proliferation / hyperplasia
210 increased hyperplasia (MESH:D006965) hepatic oval stem cell (CL:0002196) 854: Alterations, Cellular proliferation / hyperplasia
211 increased hyperplasia (MESH:D006965) intrahepatic bile duct epithelial cell (CL:0002538) 854: Alterations, Cellular proliferation / hyperplasia
212 increased Bile Duct Neoplasms (MESH:D001650) 856: Formation, Hepatocellular and Bile duct tumors
213 decreased iodide peroxidase activity (GO:0004447) thyroid peroxidase (PR:000016584) 279: Thyroperoxidase, Inhibition
214 decreased thyroid hormone generation (GO:0006590) thyroid hormone (CHEBI:60311) 277: Thyroid hormone synthesis, Decreased
215 decreased learning or memory (GO:0007611) 402: Cognitive function, decreased
216 decreased cognition (GO:0050890) 402: Cognitive function, decreased
217 decreased vascular endothelial growth factor receptor 2 binding (GO:0043184) vascular endothelial growth factor receptor 2 (PR:000002112) 305: Inhibition, VegfR2
218 decreased vascular endothelial growth factor receptor 2 binding (GO:0043184) vascular endothelial growth factor receptor 1 (PR:000007563) 305: Inhibition, VegfR2
219 decreased angiogenesis (GO:0001525) 28: Reduction, Angiogenesis
220 abnormal endothelium development (GO:0003158) 110: Impairment, Endothelial network
221 decreased blood circulation (GO:0008015) blood (UBERON:0000178) 298: Insufficiency, Vascular
222 abnormal capillary plexus (UBERON:0035753) 298: Insufficiency, Vascular
223 morphological change anatomical structure morphogenesis (GO:0009653) 1001: Increased, Developmental Defects
224 abnormal DNA alkylation (GO:0006305) Nuclear deoxyribonucleic acid (FMA:67194) 373: Formation, Pro-mutagenic DNA Adducts
225 increased metabolic process (GO:0008152) 409: Metabolism of AFB1, Production of Reactive Electrophiles