Key Event Components

Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
A complete list of all KECs is available in TSV format on the Downloads Page.

Showing 826 to 850 of 1159 KECs

ID	Action	Process	Object	Associated Key Events (KEs)


334	increased	locomotion (GO:0040011)		622: Increased, locomotion
333	increased	membrane depolarization (GO:0051899)		599: prolonged, Depolarization of neuronal membrane
332	increased	neurotransmitter secretion (GO:0007269)		600: Overactivation, Neuronotransmitter release
331	decreased	potassium channel inhibitor activity (GO:0019870)	potassium voltage-gated channel subfamily H member 2 (human) (PR:Q12809)	593: Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel
330	decreased	hypoxia (MP:0005039)		590: N/A, hypoxia
329	increased		Amputation, Congenital (MESH:C565682)	591: Increased, amputations
328	decreased	life span trait (VT:0005372)		2 Events 592: Reduced, survival 636: Decreased, survival
327	decreased	aquatic locomotion (NBO:0000371)		2 Events 586: Reduced, swimming speed 1005: Reduced, Swimming performance
326	decreased	action potential (GO:0001508)		585: Decreased, Sodium conductance 1
325	decreased	sodium channel inhibitor activity (GO:0019871)	sodium channel protein type 1 subunit alpha (PR:000002095)	2 Events 584: Inhibition, sodium channel 598: modulation, sodium channel
324	increased	predatory behavior (GO:0002120)		2 Events 588: Increased, predation 623: Increase, predation
323	decreased	receptor regulator activity (GO:0030545)		663: Desensitization, Nicotinic acetylcholine receptor
322	increased	acetylcholine receptor activator activity (GO:0030549)	Nicotinic acetylcholine receptor (FMA:61796)	663: Desensitization, Nicotinic acetylcholine receptor
321	abnormal	calmodulin binding (GO:0005516)	calcium ion (CHEBI:39124)	1243: Altered, Ca2+-calmodulin activated signal transduction
320	decreased	feeding behavior (NBO:0000079)		3 Events 561: Reduced, Food storage 587: Reduced, feeding 1 1016: Inhibition, Feeding
319	decreased	hydrogen peroxide biosynthetic process (GO:0050665)	hydrogen peroxide (CHEBI:16240)	579: Decreased, Hydrogen peroxide production
318	decreased	glucose oxidase activity (GO:0046562)	D-glucono-1,5-lactone (CHEBI:16217)	578: Decreased, Glucose oxidase enzyme activity
317	abnormal	developmental process (GO:0032502)		577: impaired, Development
316	increased	increased susceptibility to viral infection (MP:0002418)		576: Increased, Viral susceptibility
315	decreased	abnormal maternal nurturing (MP:0001386)		565: Reduced, Brood care
314	increased	Appetite (MESH:D001066)		574: Increased, Appetite and hunger
313	increased	Stress, Physiological (MESH:D013312)		2 Events 573: Increase, Energetic demands and therefore metabolic stress 1110: Increased, Energetic demands and therefore metabolic stress
312	increased	increased energy expenditure (MP:0004889)		2 Events 573: Increase, Energetic demands and therefore metabolic stress 1110: Increased, Energetic demands and therefore metabolic stress
311	decreased		population of organisms (PCO:0000001)	572: Decrease, Number of worker bees
310	abnormal	DNA repair (GO:0006281)	Mitochondrial deoxyribonucleic acid (FMA:67199)	664: Overwhelmed, Mitochondrial DNA repair mechanisms