API XML

Aop: 65

AOP Title

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XX Inhibition of Sodium Iodide Symporter and Subsequent Adverse Neurodevelopmental Outcomes in Mammals

Short name:

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NIS and Neurodevelopment

Graphical Representation

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Click to download graphical representation template

Authors

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Mary Gilbert, National Health and Environmental Effects Research Laboratory, US EPA, RTP, NC USA <gilbert.mary@epa.gov>

Anna Price, European Commission Joint Research Centre, Institute for Health and Consumer Protection, Ispra, Italy <anna.price@jrc.ec.europa.eu>

Kevin Crofton, National Center for Computational Toxicology, US EPA, RTP, NC USA <crofton.kevin@epa.gov>

Point of Contact

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Kevin Crofton   (email point of contact)

Contributors

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  • Kevin Crofton

Status

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Author status OECD status OECD project SAAOP status
Not under active development Archived


This AOP was last modified on December 03, 2016 16:37

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Revision dates for related pages

Page Revision Date/Time
Inhibition, Na+/I- symporter (NIS) April 04, 2019 08:52
Thyroid hormone synthesis, Decreased August 11, 2018 13:21
Thyroxine (T4) in serum, Decreased April 04, 2019 09:05
Thyroxine (T4) in neuronal tissue, Decreased April 04, 2019 09:13
Altered, Neuroanatomy September 16, 2017 10:15
Altered, Neurophysiology September 16, 2017 10:15
Cognitive Function, Decreased August 09, 2018 11:55
Inhibition, Na+/I- symporter (NIS) leads to TH synthesis, Decreased December 03, 2016 16:37
TH synthesis, Decreased leads to T4 in serum, Decreased April 04, 2019 10:47
T4 in serum, Decreased leads to T4 in neuronal tissue, Decreased April 04, 2019 10:50
T4 in serum, Decreased leads to Cognitive Function, Decreased August 11, 2018 19:44
Altered, Neuroanatomy leads to Altered, Neurophysiology November 29, 2016 19:59
Altered, Neurophysiology leads to Cognitive Function, Decreased November 29, 2016 20:09

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
1 MIE 424 Inhibition, Na+/I- symporter (NIS) Inhibition, Na+/I- symporter (NIS)
2 KE 277 Thyroid hormone synthesis, Decreased TH synthesis, Decreased
3 KE 281 Thyroxine (T4) in serum, Decreased T4 in serum, Decreased
4 KE 280 Thyroxine (T4) in neuronal tissue, Decreased T4 in neuronal tissue, Decreased
5 KE 186 Altered, Neuroanatomy Altered, Neuroanatomy
6 KE 192 Altered, Neurophysiology Altered, Neurophysiology
7 AO 402 Cognitive Function, Decreased Cognitive Function, Decreased

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
Inhibition, Na+/I- symporter (NIS) leads to TH synthesis, Decreased adjacent High Moderate
TH synthesis, Decreased leads to T4 in serum, Decreased adjacent High Moderate
T4 in serum, Decreased leads to T4 in neuronal tissue, Decreased adjacent Moderate Low
Altered, Neuroanatomy leads to Altered, Neurophysiology adjacent Moderate Low
Altered, Neurophysiology leads to Cognitive Function, Decreased adjacent Moderate Low
T4 in serum, Decreased leads to Cognitive Function, Decreased non-adjacent High Moderate

Network View

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Stressors

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Life Stage Applicability

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Life stage Evidence
Foetal High
Perinatal High

Taxonomic Applicability

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Term Scientific Term Evidence Link
Rattus sp. Rattus sp. High NCBI
human Homo sapiens High NCBI

Sex Applicability

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Sex Evidence
Male High
Female High

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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