AOP-Wiki

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All Key Events

Showing 676 to 700 of 1907 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1119	Failure in gamma-glutamyl carboxylation of glutamine residues on clotting factors II, VII, IX and X, Under carboxylation of clotting factors (e.g., des-gamma-carboxy prothrombin) Short Name	0		Nov 29, 2016	Nov 29, 2016	None
1120	Under carboxylated clotting factors will not assemble on cell surfaces , Failure to form clot Short Name	0		Nov 29, 2016	Nov 29, 2016	None
1121	Hemorrhage , organ dysfunction, hypovolemic shock Short Name	0		Nov 29, 2016	Nov 29, 2016	None
1122	Under carboxylated clotting factors will not assemble on cell surfaces to form clot, Failure of secondary hemostasis Short Name	1	Tissue	Nov 29, 2016	Dec 3, 2016	187: Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
1123	Hemorrhage, organ dysfunction, hypovolemic shock, Impaired oxygen delivery to tissue Short Name	0		Nov 29, 2016	Nov 29, 2016	None
1124	Hemorrhage , Impaired oxygen delivery and nutrient delivery to tissue, impaired carbon dioxide and waste product removal Short Name	0		Nov 29, 2016	Nov 29, 2016	None
1125	Impaired oxygen and nutrient delivery to tissue, impaired removal of carbon dioxide and other waste products, Hemorrhage, organ dysfunction and hypovolemic shock Short Name	0		Nov 29, 2016	Nov 29, 2016	None
1126	Unresolved blood loss, Failure in vascular repair mechanisms Short Name	0		Nov 29, 2016	Nov 29, 2016	None
1127	Anemia, Impaired oxygen and nutrient delivery to tissue, impaired carbon dioxide and waste product removal Short Name	0		Nov 29, 2016	Nov 29, 2016	None
1128	Unresolved hemorrhage, Failure in vascular repair mechanisms Short Name	0		Nov 29, 2016	Nov 29, 2016	None
1129	Unresolved blood loss (hemorrhage), Failure in vascular repair mechanisms Short Name	0		Nov 29, 2016	Nov 29, 2016	None
1130	Failure in vascular repair mechanisms, Unresolved blood loss (hemorrhage) Short Name	2	Organ	Nov 29, 2016	Sep 16, 2017	187: Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
1131	Failure in gamma-glutamyl carboxylation of clotting factors II, VII, IX and X, Under carboxylation of clotting factors (e.g., des-gamma-carboxy prothrombin) Short Name	4	Molecular	Nov 29, 2016	Dec 3, 2016	187: Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
1132	Blood loss and development of anemia, Impaired oxygen delivery and nutrient delivery to tissue, impaired carbon dioxide and waste product removal Short Name	3	Cellular	Nov 29, 2016	Dec 3, 2016	187: Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
1133	Hemostasis, Depletion from blood of fully functional carboxylated clotting factors Short Name	2	Tissue	Nov 29, 2016	Dec 3, 2016	187: Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
1134	Irreversible inhibition of hepatic VKOR by binding of AR at tyrosine 139, Failure to cycle vitamin K epoxide to vitamin K to form vitamin K hydroquinone Short Name	3	Molecular	Nov 29, 2016	Dec 3, 2016	187: Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
1135	Reduced fitness or even mortality, Acidosis, hypovolemic shock and organ dysfunction Short Name	5	Tissue	Nov 29, 2016	Dec 3, 2016	187: Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
1136	Impaired recruitment , Population trajectory Short Name	1	Population	Nov 29, 2016	Dec 3, 2016	187: Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
1137	Under carboxylation of osteocalcin, Failure to cycle vitamin K epoxide to vitamin K to form vitamin K hydroquinone Short Name	0		Nov 29, 2016	Nov 29, 2016	None
1138	Uncoupling of oxidative phosphorylation, Reduced ability to generate ATP Short Name	2	Molecular	Nov 29, 2016	Sep 16, 2017	187: Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
1139	Increased, water retention in foot Short Name Increased, water retention in foot	0	Organ	Nov 29, 2016	Dec 3, 2016	97: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
1140	Delayed, Sexual maturity Short Name Delayed, Sexual maturity	0	Individual	Nov 29, 2016	Dec 3, 2016	None
1141	Decreased, Reproductive Success Short Name Decreased, Reproductive Success	0	Individual	Nov 29, 2016	Dec 3, 2016	4 AOPs 203: 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline 218: Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity 219: Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior 473: Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin
1142	Increased, valve movement Short Name Increased, valve movement	1	Tissue	Nov 29, 2016	Dec 3, 2016	4 AOPs 97: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline 203: 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline 204: 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase 195: 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase
1143	Depletion, energy reserves Short Name Depletion, energy reserves	0	Individual	Nov 29, 2016	Dec 3, 2016	97: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline