AOP-Wiki

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All Key Events

Showing 701 to 725 of 1907 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1144	premature, spawning 1 1 Short Name premature, spawning 1	0		Nov 29, 2016	Nov 29, 2016	None
1145	Decreased, gametogenesis Short Name Decreased, gametogenesis	0		Nov 29, 2016	Nov 29, 2016	None
1146	premature, Spawning Short Name premature, Spawning	0	Individual	Nov 29, 2016	Jan 17, 2017	None
1147	increased or inappropriate, mantel display Short Name	0	Individual	Nov 29, 2016	Dec 3, 2016	None
1148	Anticoagulant rodenticide interferes with gamma-carboxyglutamate formation, Inhibition of protein synthesis in bone Short Name	0		Nov 29, 2016	Nov 29, 2016	None
1149	Calcium cannot bind to the hydroxyapatite matrix of bone, Osteocalcin and other bone proteins (periostin, MGP and periostin like factor) not formed Short Name	0		Nov 29, 2016	Nov 29, 2016	None
1150	Uncarboxylated osteocalcin not incorporated into bone matrix, decreasing bone strength, Impaired function of osteocalcin and MGP Short Name	0		Nov 29, 2016	Nov 29, 2016	None
1151	Osteoporosis and vascular calcification, Bone deterioration Short Name	2	Individual	Nov 29, 2016	Dec 3, 2016	187: Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
1152	Inhibition, Iodotyrosine deiodinase (IYD) Short Name	1	Molecular	Nov 29, 2016	Nov 18, 2025	188: Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis
1153	Inhibition, Deiodinase 3 Short Name Inhibition, Deiodinase 3	1	Molecular	Nov 29, 2016	Nov 19, 2025	191: Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis
1154	Increased, Triiodothyronine (T3) in tissues Short Name	1	Tissue	Nov 29, 2016	Dec 3, 2016	191: Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis
1155	Inhibition, Pendrin Short Name Inhibition, Pendrin	1	Molecular	Nov 29, 2016	Nov 19, 2025	192: Pendrin inhibition leading to altered amphibian metamorphosis
1156	Inhibition, Dual oxidase Short Name Inhibition, Dual oxidase	1	Molecular	Nov 29, 2016	Nov 19, 2025	193: Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis
1157	Activation, Hepatic nuclear receptor(s) Short Name Activation, Hepatic nuclear receptor(s)	1	Molecular	Nov 29, 2016	Nov 19, 2025	194: Hepatic nuclear receptor activation leading to altered amphibian metamorphosis
1158	Increased, Hepatic thyroid hormone uptake/transport Short Name	1	Tissue	Nov 29, 2016	Sep 16, 2017	4 AOPs 194: Hepatic nuclear receptor activation leading to altered amphibian metamorphosis 366: Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis 367: Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis 393: AOP for thyroid disorder caused by triphenyl phosphate via TRβ activation
1159	Increased, reuptake of 5-HT (5-hydroxytryptamine transporter; sodium-dependent serotonin transporter Short Name	0		Nov 29, 2016	Nov 29, 2016	None
1160	Increased, mantel display Short Name Increased, mantel display	0	Individual	Nov 29, 2016	Dec 3, 2016	None
1161	Increased, oocyte maturation Short Name Increased, oocyte maturation	1	Organ	Nov 29, 2016	Jan 17, 2017	195: 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase
1162	Increased, cilia movement Short Name Increased, cilia movement	0	Cellular	Nov 29, 2016	Dec 3, 2016	None
1163	Increased, Reproductive Success Short Name Increased, Reproductive Success	1	Individual	Nov 29, 2016	Dec 3, 2016	2 AOPs 204: 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase 195: 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase
1164	Increased, Population Short Name Increased, Population	1	Population	Nov 29, 2016	Dec 3, 2016	2 AOPs 195: 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase 204: 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase
1165	Vitamin K inhibition, gamma-carboxylation of glutamate to Gla residues reduced in bone proteins e.g., periostin Short Name	0		Nov 29, 2016	Nov 29, 2016	None
1166	Increased, water pumping Short Name Increased, water pumping	0	Tissue	Nov 29, 2016	Dec 3, 2016	None
1167	induced, parturition Short Name induced, parturition	0	Individual	Nov 29, 2016	Dec 3, 2016	None
1168	Undercarboxylation of osteocalcin , Affects bone formation (osteoblast-osteoclast interaction, bone resorption) and glucose and lipid hoemostasis Short Name	0		Nov 29, 2016	Nov 29, 2016	None