AOP-Wiki

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All Key Events

Showing 326 to 350 of 1939 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

2114	Disturbed, cortical architecture Short Name Disturbed cortical architecture	0	Organ	Feb 21, 2023	Feb 21, 2023	486: Binding to the extracellular protein laminin leading to decreased cognitive function
2113	Decreased, radial glia cell density Short Name RG density	0	Cellular	Feb 21, 2023	Feb 21, 2023	486: Binding to the extracellular protein laminin leading to decreased cognitive function
2112	Disturbed, radial glia cell alignment and migration Short Name RG alignment and migration	0	Cellular	Feb 21, 2023	Feb 21, 2023	486: Binding to the extracellular protein laminin leading to decreased cognitive function
2111	Decreased, neural progenitor cell adhesion to laminin Short Name NPC adhesion to laminin	0	Cellular	Feb 21, 2023	Feb 21, 2023	486: Binding to the extracellular protein laminin leading to decreased cognitive function
2110	Disrupted binding, laminin-beta1-integrin receptors with laminin Short Name	0	Molecular	Feb 21, 2023	Feb 21, 2023	486: Binding to the extracellular protein laminin leading to decreased cognitive function
2109	Binding, extracellular matrix protein laminin Short Name Binding to laminin	0	Molecular	Feb 21, 2023	Feb 21, 2023	486: Binding to the extracellular protein laminin leading to decreased cognitive function
2108	Altered, white brain matter Short Name Altered, white brain matter	0	Tissue	Feb 21, 2023	Feb 21, 2023	6 AOPs 485: Thyroid hormone antagonism leading to impaired oligodendrocyte maturation during development and subsequent decreased cognition 487: Unknown MIE altering cholesterol metabolism leading to decreased cognition 488: Increased reactive oxygen species production leading to decreased cognitive function 489: Inhibition of voltage-gated sodium channels leading to decreased cognition 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
2107	Hypomyelination Short Name Hypomyelination	0	Tissue	Feb 21, 2023	Feb 21, 2023	7 AOPs 485: Thyroid hormone antagonism leading to impaired oligodendrocyte maturation during development and subsequent decreased cognition 487: Unknown MIE altering cholesterol metabolism leading to decreased cognition 488: Increased reactive oxygen species production leading to decreased cognitive function 489: Inhibition of voltage-gated sodium channels leading to decreased cognition 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory 605: Thyroid Peroxidase Inhibition Leading to Reduced, Swimming Performance via Hypomyelination 608: Thyroid Hormone Excess Leading to Reduced, Swimming Performance via Hypomyelination
2106	Impaired, oligodendrocyte maturation Short Name Impaired OL maturation	0	Cellular	Feb 21, 2023	Feb 21, 2023	3 AOPs 485: Thyroid hormone antagonism leading to impaired oligodendrocyte maturation during development and subsequent decreased cognition 605: Thyroid Peroxidase Inhibition Leading to Reduced, Swimming Performance via Hypomyelination 608: Thyroid Hormone Excess Leading to Reduced, Swimming Performance via Hypomyelination
2105	Decreased, myelin basic protein expression in oligodendrocytes Short Name	0	Molecular	Feb 21, 2023	Feb 21, 2023	2 AOPs 485: Thyroid hormone antagonism leading to impaired oligodendrocyte maturation during development and subsequent decreased cognition 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
2104	Decreased, thyroid hormone binding to thyroid hormone receptor Short Name Decreased, TH binding to THR	0	Molecular	Feb 21, 2023	Feb 21, 2023	485: Thyroid hormone antagonism leading to impaired oligodendrocyte maturation during development and subsequent decreased cognition
2103	Cellular dysfunction (human placenta trophoblast cells) Short Name	0	Cellular	Feb 7, 2023	Feb 7, 2023	None
2102	Cytotoxicity (human trophoblast cells) Short Name Cytotoxicity (human trophoblast cells)	0	Cellular	Feb 7, 2023	Feb 7, 2023	None
2101	Conformational changes of thyroid receptor Short Name	0	Molecular	Feb 7, 2023	Feb 7, 2023	None
2100	Inhibition of rapid delayed rectifying potassium current Short Name	0	Cellular	Jan 29, 2023	Jan 29, 2023	433: hERG channel blockade leading to sudden cardiac death
2099	hERG channel blockade Short Name hERG channel blockade	0	Molecular	Jan 29, 2023	Jan 29, 2023	433: hERG channel blockade leading to sudden cardiac death
2098	Increase, Abnormal Neural Remodeling Short Name Abnormal Neural Remodeling	3	Tissue	Jan 25, 2023	Jul 26, 2024	483: Deposition of Energy Leading to Learning and Memory Impairment
2097	Increase, Pro-Inflammatory Mediators Short Name Increase, Pro-Inflammatory Mediators	1	Tissue	Jan 25, 2023	Jul 26, 2024	483: Deposition of Energy Leading to Learning and Memory Impairment
2096	Occurrence, (Micro)vascular dysfunction Short Name (Micro)vascular dysfunction	4	Tissue	Jan 23, 2023	Jul 31, 2023	385: Viral spike protein interaction with ACE2 leads to microvascular dysfunction, via ACE2 dysregulation
2095	Periventricular heterotopia formation Short Name Heterotopia formation	0	Individual	Jan 19, 2023	Jan 19, 2023	402: Thyroid peroxidase (TPO) inhibition leads to periventricular heterotopia formation in the developing rat brain
2094	Abnormal, neuroblast migration Short Name Abnormal cell migration in brain	0	Cellular	Jan 19, 2023	Jan 19, 2023	402: Thyroid peroxidase (TPO) inhibition leads to periventricular heterotopia formation in the developing rat brain
2093	Brain thyroid hormone (T4/T3) decreased Short Name Decreased brain T4/T3	0	Organ	Jan 19, 2023	Jan 19, 2023	2 AOPs 402: Thyroid peroxidase (TPO) inhibition leads to periventricular heterotopia formation in the developing rat brain 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
2092	Promotion, Ovarian Cancer Short Name Promotion, Ovarian Cancer	1	Organ	Jan 12, 2023	Mar 11, 2023	440: Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
2091	Occurrence, Bone Loss Short Name Bone Loss	2	Organ	Jan 11, 2023	Aug 23, 2024	482: Deposition of energy leading to occurrence of bone loss
2090	Increase, Bone Remodeling Short Name Bone Remodeling	3	Tissue	Jan 11, 2023	Aug 13, 2024	482: Deposition of energy leading to occurrence of bone loss