AOP-Wiki

API

All Key Events

Showing 426 to 450 of 1939 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

2013	Airway remodeling Short Name Airway remodeling	0	Organ	May 31, 2022	May 31, 2022	452: Adverse outcome pathway of PM-induced respiratory toxicity
2012	Fibroblast proliferation and differentiation Short Name	0	Cellular	May 31, 2022	May 31, 2022	452: Adverse outcome pathway of PM-induced respiratory toxicity
2011	Emphysema Short Name Emphysema	0	Organ	May 31, 2022	May 31, 2022	452: Adverse outcome pathway of PM-induced respiratory toxicity
2010	Pulmonary inflammation Short Name Pulmonary inflammation	0	Organ	May 31, 2022	May 31, 2022	2 AOPs 452: Adverse outcome pathway of PM-induced respiratory toxicity 481: AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases.
2009	Activation of inflammation pathway Short Name Activation, inflammation pathway	0	Cellular	May 31, 2022	May 31, 2022	4 AOPs 452: Adverse outcome pathway of PM-induced respiratory toxicity 507: Nrf2 inhibition leading to vascular disrupting effects via inflammation pathway 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects 638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis
2008	Chronic obstructive pulmonary disease Short Name Chronic obstructive pulmonary disease	0	Individual	May 31, 2022	May 31, 2022	452: Adverse outcome pathway of PM-induced respiratory toxicity
2007	Non-coding RNA expression profile alteration Short Name Non-coding RNA expression，alteration	0	Molecular	May 31, 2022	May 31, 2022	452: Adverse outcome pathway of PM-induced respiratory toxicity
2006	Secondary genotoxicity Short Name Secondary genotoxicity	1	Cellular	May 25, 2022	May 25, 2022	451: Interaction with lung resident cell membrane components leads to lung cancer
2005	Altered neurotransmission in development Short Name neurotrasmission in development	1	Cellular	May 16, 2022	Jul 24, 2024	442: Binding to voltage gate sodium channels during development leads to cognitive impairment
2004	Increased, secretion of catecholamine Short Name Increased, secretion of catecholamine	0	Cellular	Apr 22, 2022	Apr 22, 2022	None
2003	Vascular remodeling Short Name Vascular remodeling	0	Organ	Apr 22, 2022	Apr 22, 2022	None
2002	Ventricular remodeling Short Name Ventricular remodeling	0	Organ	Apr 22, 2022	Apr 22, 2022	None
2001	Cardiac hypertrophy Short Name Cardiac hypertrophy	0	Organ	Apr 22, 2022	Apr 22, 2022	None
2000	Vascular calcification Short Name Vascular calcification	0	Organ	Apr 21, 2022	Apr 21, 2022	None
1999	Increased mortality of neurodegenerative diseases Short Name	0	Population	Apr 7, 2022	Apr 7, 2022	None
1998	Activation, Microglia Short Name Microglia activation	0	Cellular	Apr 7, 2022	Apr 7, 2022	490: Co-activation of IP3R and RyR leads to reduced IQ and increased socio-economic burden through non-cholinergic mechanisms
1997	Colon epithelial injury Short Name Colon epithelial injury	0	Organ	Apr 7, 2022	Apr 7, 2022	None
1996	Increased incidence of digestive morbidity and mortality in the general population Short Name	0	Population	Apr 7, 2022	Apr 7, 2022	None
1995	Abnormal lipid metabolism Short Name Abnormal lipid metabolism	0	Cellular	Apr 7, 2022	Apr 7, 2022	2 AOPs 401: G protein-coupled estrogen receptor 1 (GPER) signal pathway in the lipid metabolism disrupting effects 646: Binding and activation of AhR/PPARγ lead to lipid metabolism disorders
1994	Increase, Ferroptosis Short Name Ferroptosis	0	Cellular	Apr 7, 2022	Apr 7, 2022	615: Suppression of Keap1 cysteine oxidation leading to liver inflammation
1993	Increase, Pneumonia Short Name Pneumonia	0	Organ	Apr 7, 2022	Apr 7, 2022	None
1992	Increased incidence of respiratory morbidity and mortality in the general population Short Name	0	Population	Apr 7, 2022	Apr 7, 2022	None
1991	Impaired, Reproduction Short Name Impaired, Reproduction	0	Population	Apr 5, 2022	Apr 5, 2022	445: Estrogen Receptor Alpha Agonism leads to Impaired Reproduction
1990	Increased, Oocyte Atresia Short Name Increased, Oocyte Atresia	0	Tissue	Apr 5, 2022	Apr 5, 2022	445: Estrogen Receptor Alpha Agonism leads to Impaired Reproduction
1989	Impaired, Oocyte maturation and ovulation Short Name	0	Tissue	Apr 5, 2022	Apr 5, 2022	445: Estrogen Receptor Alpha Agonism leads to Impaired Reproduction