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All Key Events

Showing 126 to 150 of 1939 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

2317	Loss of olfactory function Short Name Loss of olfactory function	1	Organ	Mar 13, 2025	Mar 25, 2025	574: Inhibition, cytochrome oxidase leads to Loss of olfactory function
2316	Increased, pulmonary edema Short Name Increased, pulmonary edema	1	Organ	Mar 12, 2025	Mar 24, 2025	573: Inhibition, cytochrome oxidase leads to Increased, pulmonary edema
2315	Increased, Incidence of cardiovascular disease Short Name	0	Population	Mar 11, 2025	Mar 11, 2025	None
2314	Increased, Cardiovascular dysfunction Short Name Cardiovascular dysfunction	0	Individual	Mar 11, 2025	Mar 11, 2025	None
2313	Increased, Cardiovascular fibrosis Short Name Increased, Cardiovascular fibrosis	0	Organ	Mar 11, 2025	Mar 11, 2025	None
2312	Increased, nasal lesions Short Name Increased, nasal lesions	1	Organ	Mar 5, 2025	Mar 19, 2025	368: Cytochrome oxidase inhibition leading to increased nasal lesions
2311	Inhibition of PI3K-Akt pathway Short Name PI3K-Akt pathway	0	Molecular	Mar 2, 2025	Mar 2, 2025	569: Decreased DNA methylation of FAM50B/PTCHD3 leading to IQ loss of children via PI3K-Akt pathway
2310	Elevated gene expression of FAM50B/PTCHD3 Short Name FAM50B/PTCHD3 expression	0	Molecular	Mar 2, 2025	Mar 2, 2025	569: Decreased DNA methylation of FAM50B/PTCHD3 leading to IQ loss of children via PI3K-Akt pathway
2309	Decreased DNA methylation of FAM50B/PTCHD3 Short Name FAM50B/PTCHD3 methylation	0	Molecular	Mar 2, 2025	Mar 2, 2025	569: Decreased DNA methylation of FAM50B/PTCHD3 leading to IQ loss of children via PI3K-Akt pathway
2308	Increased, stimulation of brain serotonin 5-HT1a, 5-HT2c receptors Short Name	3	Organ	Jan 14, 2025	Feb 13, 2025	568: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) leads to Inhibition, Feeding
2307	Binding of plastoquinone B (QB) within D1 protein of Photosystem II Short Name Binding to the QB site D1 protein	0	Molecular	Jan 14, 2025	Feb 4, 2026	567: Binding to plastoquinone B site leading to decreased population growth rate via photosystem II inhibition
2306	Persistent vaginal cornification Short Name Persistent vaginal cornification	1	Tissue	Jan 13, 2025	Jan 29, 2026	2 AOPs 566: Decreased, GnRH pulsatility/release leading to estradiol availability, increased via impaired ovulation 623: Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release
2305	Premature ovarian Insufficiency Short Name POI	1	Organ	Jan 12, 2025	May 7, 2025	563: Aryl hydrocarbon Receptor (AHR) activation causes Premature Ovarian Insufficiency via Bax mediated apoptosis
2303	Increased plasma estradiol to progesterone ratio (estrogen dominance/unopposed estrogen) Short Name	0	Organ	Jan 3, 2025	Jan 3, 2025	566: Decreased, GnRH pulsatility/release leading to estradiol availability, increased via impaired ovulation
2302	Increase, Malformations Short Name Increase, Malformations	0	Population	Dec 24, 2024	Jan 20, 2025	564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity.
2301	Abnormal, Behavior Short Name Abnormal, Behavior	1	Individual	Dec 24, 2024	Jan 20, 2025	564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity.
2300	Disruption, Glucolipid metabolism Short Name Disruption, Glucolipid metabolism	2	Cellular	Dec 24, 2024	Jan 20, 2025	564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity.
2299	Altered, Redox Homeostasis Short Name Altered, Redox Homeostasis	1	Molecular	Dec 24, 2024	Jan 20, 2025	564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity.
2298	Decrease, intratesticular testosterone levels Short Name Decrease, intratesticular testosterone	1	Organ	Dec 12, 2024	Mar 20, 2026	3 AOPs 307: Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring 570: Decreased testosterone synthesis leading to hypospadias in male (mammalian) offspring 575: Decreased testosterone synthesis leading to increased nipple retention (NR) in male (rodent) offspring
2297	Serum bile acid levels, Altered Short Name Bile acid alterations	0	Cellular	Nov 25, 2024	Nov 25, 2024	None
2296	Reduced Pacemaker Activity in SA Node Short Name Reduced Pacemaker Activity in SA Node	0	Cellular	Nov 24, 2024	Nov 25, 2024	562: HCN Channel Inhibition leading to Arrhythmias
2295	HCN Channel Inhibition Short Name HCN Channel Inhibition	0	Molecular	Nov 24, 2024	Nov 24, 2024	562: HCN Channel Inhibition leading to Arrhythmias
2294	Plasma estradiol, increased Short Name Plasma E2, increased	1	Cellular	Nov 22, 2024	Apr 6, 2026	5 AOPs 561: Aromatase induction leading to estrogen receptor alpha activation via increased estradiol 623: Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release 637: Activation, estrogen receptor alpha leads to increased uterine weight via earlier proliferation of cells of the uterine lining 639: Activation, estrogen receptor alpha leads to precocious puberty via increased kisspeptin release 640: Activation, estrogen receptor alpha leads to decreased fertility via prolonged estrus cycle
2293	Aromatase, induction Short Name Aromatase, induction	1	Molecular	Nov 22, 2024	Feb 21, 2025	561: Aromatase induction leading to estrogen receptor alpha activation via increased estradiol
2292	Altered Cardiac Electrical Conduction Short Name Altered Cardiac Electrical Conduction	0	Organ	Nov 22, 2024	Nov 22, 2024	2 AOPs 560: Inhibition of Funny current (If) leading to Arrhythmias 562: HCN Channel Inhibition leading to Arrhythmias