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ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

926	Oxidation, Glutathione (To be considered with MIE) Short Name Oxidation, Glutathione	1	Molecular	Nov 29, 2016	Nov 9, 2017	2 AOPs 284: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease 413: Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure
1287	Glutathione synthesis Short Name Glutathione synthesis	1	Cellular	Feb 15, 2017	Sep 16, 2017	209: Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
1290	Glutathione homeostasis Short Name Glutathione homeostasis	1	Cellular	Feb 15, 2017	Sep 16, 2017	209: Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP

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ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1538	Decreased protection against oxidative stress Short Name	0	Cellular	Sep 13, 2018	Jul 15, 2022	2 AOPs 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 284: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease
1632	Increase in reactive oxygen and nitrogen species (RONS) Short Name Increase in RONS	0	Molecular	May 3, 2019	May 8, 2019	5 AOPs 293: Increased DNA damage leading to increased risk of breast cancer 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer 432: Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability 473: Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin
1869	Diminished protective oxidative stress response Short Name Diminished Protective Response to ROS	3	Cellular	Apr 20, 2021	Oct 30, 2023	5 AOPs 379: Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation 406: SARS-CoV-2 infection leading to hyperinflammation 407: SARS-CoV-2 infection leading to pyroptosis 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 488: Increased reactive oxygen species production leading to decreased cognitive function
2131	Conjugation, GSH Short Name Conjugation, GSH	1	Cellular	Apr 5, 2023	Sep 14, 2023	492: Glutathione conjugation leading to reproductive dysfunction via oxidative stress
2363	Elevated mitochondrial ROS and dysfunction Short Name Mito ROS dysfunction	1	Cellular	Sep 5, 2025	Oct 3, 2025	2 AOPs 593: Redox cycling of a chemical by mitochondria leads to degeneration of nigrostriatal dopaminergic neurons 616: organic UV filter and its Photoproducts reproductive toxicity pathways