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All Key Events

Showing 601 to 625 of 1907 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1039	Increased activity, beta-2 adrenergic receptor Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	2 AOPs 164: Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse 557: β2-Receptor agonist leading to Cardiomyopathy
1040	relaxation, smooth muscle Short Name relaxation, smooth muscle	1	Tissue	Nov 29, 2016	Dec 3, 2016	164: Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse
1041	Proliferation, smooth muscle Short Name Proliferation, smooth muscle	0		Nov 29, 2016	Nov 29, 2016	None
1042	Proliferation/Clonal Expansion, smooth muscle Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	164: Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse
1043	Hypertrophy/hyperplasia, smooth muscle Short Name Hypertrophy/hyperplasia, smooth muscle	1	Cellular	Nov 29, 2016	Dec 3, 2016	164: Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse
1044	Promotion, mesovarian leiomyomas Short Name Promotion, mesovarian leiomyomas	1	Tissue	Nov 29, 2016	Sep 16, 2017	164: Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse
1045	Decreased, Ovarian E2 Short Name Decreased, Ovarian E2	1	Tissue	Nov 29, 2016	Sep 16, 2017	165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse
1046	Suppression, Estrogen receptor (ER) activity Short Name	1	Molecular	Nov 29, 2016	Feb 28, 2022	2 AOPs 165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse 440: Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
1047	Increased, secretion of GnRH from hypothalamus Short Name	1	Cellular	Nov 29, 2016	Jan 29, 2026	3 AOPs 165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse 440: Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia 623: Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release
1048	Increased, secretion of leutenizing hormone Short Name	0		Nov 29, 2016	Nov 29, 2016	None
1049	Increased, secrection of FSH from anterior pituitary Short Name	1	Cellular	Nov 29, 2016	Dec 3, 2016	165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse
1050	Increased, secretion of LH from anterior pituitary Short Name	1	Cellular	Nov 29, 2016	Dec 3, 2016	2 AOPs 165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse 440: Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
1051	Hyperplasia, ovarian stromal cells Short Name Hyperplasia, ovarian stromal cells	1	Cellular	Nov 29, 2016	Sep 16, 2017	165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse
1052	Hyperplasia, ovarian epithelium Short Name Hyperplasia, ovarian epithelium	1	Tissue	Nov 29, 2016	Sep 16, 2017	2 AOPs 165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse 440: Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
1053	Promotion, ovarian adenomas Short Name Promotion, ovarian adenomas	1	Tissue	Nov 29, 2016	Dec 3, 2016	2 AOPs 165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse 440: Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
1054	Promotion, ovarian granular cell tumors Short Name Promotion, ovarian granular cell tumors	1	Cellular	Nov 29, 2016	Dec 3, 2016	165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse
1056	Decrease, E2 blood concentrations at hypothalamus Short Name	1	Tissue	Nov 29, 2016	Sep 16, 2017	2 AOPs 165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse 153: Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats
1057	Increased, PPAR-alpha activation Short Name Increased, PPAR-alpha activation	1	Molecular	Nov 29, 2016	Sep 16, 2017	166: PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse
1058	Decreased, bile flow Short Name Decreased, bile flow	1	Organ	Nov 29, 2016	Sep 16, 2017	166: PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse
1059	Increased, cholestasis Short Name Increased, cholestasis	1	Organ	Nov 29, 2016	Sep 16, 2017	166: PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse
1060	Alteration, lipid metabolism Short Name Alteration, lipid metabolism	1	Cellular	Nov 29, 2016	Oct 30, 2023	2 AOPs 166: PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse 513: Reactive Oxygen (ROS) formation leads to cancer via Peroxisome proliferation-activated receptor (PPAR) pathway
1061	prolonged, elevation of serun CCK Short Name prolonged, elevation of serun CCK	1	Tissue	Nov 29, 2016	Sep 16, 2017	166: PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse
1062	Increased, Cellular proliferation / hyperplasia of acinar cells Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	166: PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse
1063	Increased, Pancreatic acinar tumors Short Name Increased, Pancreatic acinar tumors	1	Organ	Nov 29, 2016	Sep 16, 2017	166: PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse
1065	Activation, estrogen receptor alpha Short Name Activation, ERα	2	Molecular	Nov 29, 2016	Jan 28, 2026	7 AOPs 445: Estrogen Receptor Alpha Agonism leads to Impaired Reproduction 503: Activation of uterine estrogen receptor-alfa leading to endometrial adenocarcinoma, via epigenetic modulation 504: SULT1E1 inhibition leading to uterine adenocarcinoma via increased estrogen availability at target organ level 561: Aromatase induction leading to estrogen receptor alpha activation via increased estradiol 565: 17β-Hydroxysteroid dehydrogenase 2, inhibition leading to activation, estrogen receptor alpha 609: Activation, estrogen receptor alpha leads to prolonged estrus cycle via decreased kisspeptin release 623: Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release